Self-Reported Adverse Events of COVID-19 Vaccines in Polish
Healthcare Workers and Medical Students. Cross-Sectional Study
and Pooled Analysis of CoVaST Project Results in Central Europe

J 2021

Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe

DZIEDZIC, Arkadiusz, Abanoub RIAD, Sameh ATTIA, Miloslav KLUGAR, Marta TANASIEWICZ et. al.

Basic information

Original name

Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe

Authors

DZIEDZIC, Arkadiusz (guarantor), Abanoub RIAD (818 Egypt, belonging to the institution), Sameh ATTIA, Miloslav KLUGAR (203 Czech Republic, belonging to the institution) and Marta TANASIEWICZ

Edition

Journal of Clinical Medicine, Basel, MDPI, 2021, 2077-0383

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.964

RIV identification code

RIV/00216224:14110/21:00122863

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/jcm10225338

UT WoS

000724802400001

Keywords in English

COVID-19; adverse effects; BTN162 mRNA vaccine; vector vaccine; cross-sectional study; adverse reactions; Poland; healthcare workers; pooled analysis; prevalence

Abstract

V originále

Background: Optimization of COVID-19 vaccination rate among healthcare personnel is of utmost priority to secure provision of uninterrupted care and to protect the most vulnerable patients. This study, as part of the global CoVaST project, aimed to assess the occurrence of short-term adverse events (SRAEs) of two most administered COVID-19 vaccines, mRNA-based (Pfizer-BioNTech and Moderna) and viral vector-based (AstraZeneca) in healthcare sector workers (HWs). Methods: A cross-sectional survey-based study was carried out for the first time among 317 Polish healthcare sector personnel and medical students using a validated and pre-tested questionnaire. The online questionnaire included 25 pre-tested, validated questions concerning demographic data, medical parameters, COVID-19-related anamneses, and local or systemic reactions (reactogenicity) associated with COVID-19 vaccination. Descriptive statistics, inferential tests and binary logistic regression were performed. Results: Out of the 247 participating HWs, 79.8% were females, and 77.5% received mRNA-based vaccines, while 24.5% received a viral vector-based vaccine. Cumulatively, 78.9% and 60.7% of the participants reported at least one local and one systemic SRAE respectively, following their COVID-19 first or second dose of vaccine. A wide array of SRAEs was observed, while pain at injection site (76.9%) was the most common local SRAE, and fatigue (46.2%), headache (37.7%), muscle pain (31.6%) were the most common systemic SRAEs. The vast proportion of local (35.2%) and systemic (44.8%) SRAEs subsided up to 1 day after inoculation with both types of vaccines. The mRNA-based vaccine versions seem to cause higher prevalence of local SRAEs, mainly pain within injection site (81.3% vs. 71.7%; p = 0.435), while the viral vector-based vaccine was linked with increased incidents of mild systemic side effects (76.7% vs. 55.3%; p = 0.004) after both doses. Pooled analysis revealed uniform results while comparing the prevalence of SRAEs in HWs as recipients in four central European countries (OR = 2.38; 95% CI = 2.03–2.79). Conclusions: The study confirmed the safety of commonly administered vaccines against COVID-19, which were associated with mild, self-resolving adverse events. No major vaccine-related incidents were reported which would affect every day functioning, significantly. The younger age group (below 29 y.o.) were associated with an increased risk of adverse events generally. The results enhanced current data regarding COVID-19 vaccination active surveillance in selected occupational groups.

Links

LTC20031, research and development project

Name: Towards an International Network for Evidence-based Research in Clinical Health Research in the Czech Republic

Investor: Ministry of Education, Youth and Sports of the CR, INTER-COST

MUNI/A/1608/2020, interní kód MU

Name: Prohlubování znalostí v oblasti zdravotních rizik a benefitů výživy, prostředí a životního stylu III

Investor: Masaryk University

MUNI/IGA/1543/2020, interní kód MU

Name: Evidence-based Practice of Healthcare Professionals and Students in the Czech Republic (Acronym: Evidence-Based Practice in Czechia)

Investor: Masaryk University

Citovat

DZIEDZIC, Arkadiusz, Abanoub RIAD, Sameh ATTIA, Miloslav KLUGAR and Marta TANASIEWICZ. Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe. Journal of Clinical Medicine. Basel: MDPI, 2021, vol. 10, No 22, p. 1-24. ISSN 2077-0383. Available from: https://dx.doi.org/10.3390/jcm10225338.

@article{1803887,
   author = {Dziedzic, Arkadiusz and Riad, Abanoub and Attia, Sameh and Klugar, Miloslav and Tanasiewicz, Marta},
   article_location = {Basel},
   article_number = {22},
   doi = {http://dx.doi.org/10.3390/jcm10225338},
   keywords = {COVID-19; adverse effects; BTN162 mRNA vaccine; vector vaccine; cross-sectional study; adverse reactions; Poland; healthcare workers; pooled analysis; prevalence},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe},
   url = {https://www.mdpi.com/2077-0383/10/22/5338},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1803887
AU  - Dziedzic, Arkadiusz - Riad, Abanoub - Attia, Sameh - Klugar, Miloslav - Tanasiewicz, Marta
PY  - 2021
TI  - Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe
JF  - Journal of Clinical Medicine
VL  - 10
IS  - 22
SP  - 1-24
EP  - 1-24
PB  - MDPI
SN  - 20770383
KW  - COVID-19
KW  - adverse effects
KW  - BTN162 mRNA vaccine
KW  - vector vaccine
KW  - cross-sectional study
KW  - adverse reactions
KW  - Poland
KW  - healthcare workers
KW  - pooled analysis
KW  - prevalence
UR  - https://www.mdpi.com/2077-0383/10/22/5338
N2  - Background: Optimization of COVID-19 vaccination rate among healthcare personnel is of utmost priority to secure provision of uninterrupted care and to protect the most vulnerable patients. This study, as part of the global CoVaST project, aimed to assess the occurrence of short-term adverse events (SRAEs) of two most administered COVID-19 vaccines, mRNA-based (Pfizer-BioNTech and Moderna) and viral vector-based (AstraZeneca) in healthcare sector workers (HWs). Methods: A cross-sectional survey-based study was carried out for the first time among 317 Polish healthcare sector personnel and medical students using a validated and pre-tested questionnaire. The online questionnaire included 25 pre-tested, validated questions concerning demographic data, medical parameters, COVID-19-related anamneses, and local or systemic reactions (reactogenicity) associated with COVID-19 vaccination. Descriptive statistics, inferential tests and binary logistic regression were performed. Results: Out of the 247 participating HWs, 79.8% were females, and 77.5% received mRNA-based vaccines, while 24.5% received a viral vector-based vaccine. Cumulatively, 78.9% and 60.7% of the participants reported at least one local and one systemic SRAE respectively, following their COVID-19 first or second dose of vaccine. A wide array of SRAEs was observed, while pain at injection site (76.9%) was the most common local SRAE, and fatigue (46.2%), headache (37.7%), muscle pain (31.6%) were the most common systemic SRAEs. The vast proportion of local (35.2%) and systemic (44.8%) SRAEs subsided up to 1 day after inoculation with both types of vaccines. The mRNA-based vaccine versions seem to cause higher prevalence of local SRAEs, mainly pain within injection site (81.3% vs. 71.7%; p = 0.435), while the viral vector-based vaccine was linked with increased incidents of mild systemic side effects (76.7% vs. 55.3%; p = 0.004) after both doses. Pooled analysis revealed uniform results while comparing the prevalence of SRAEs in HWs as recipients in four central European countries (OR = 2.38; 95% CI = 2.03–2.79). Conclusions: The study confirmed the safety of commonly administered vaccines against COVID-19, which were associated with mild, self-resolving adverse events. No major vaccine-related incidents were reported which would affect every day functioning, significantly. The younger age group (below 29 y.o.) were associated with an increased risk of adverse events generally. The results enhanced current data regarding COVID-19 vaccination active surveillance in selected occupational groups.
ER  -

DZIEDZIC, Arkadiusz, Abanoub RIAD, Sameh ATTIA, Miloslav KLUGAR and Marta TANASIEWICZ. Self-Reported Adverse Events of COVID-19 Vaccines in Polish Healthcare Workers and Medical Students. Cross-Sectional Study and Pooled Analysis of CoVaST Project Results in Central Europe. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, vol.~10, No~22, p.~1-24. ISSN~2077-0383. Available from: https://dx.doi.org/10.3390/jcm10225338.

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