Diffusion magnetic resonance imaging reveals tract-specific
microstructural correlates of electrophysiological impairments
in non-myelopathic and myelopathic spinal cord compression

J 2021

Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression

VALOSEK, Jan, Rene LABOUNEK, Tomáš HORÁK, Magda HORÁKOVÁ, Petr BEDNAŘÍK et. al.

Basic information

Original name

Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression

Authors

VALOSEK, Jan (203 Czech Republic), Rene LABOUNEK (203 Czech Republic), Tomáš HORÁK (203 Czech Republic, belonging to the institution), Magda HORÁKOVÁ (203 Czech Republic, belonging to the institution), Petr BEDNAŘÍK (203 Czech Republic, belonging to the institution), Miloš KEŘKOVSKÝ (203 Czech Republic, belonging to the institution), Jan KOČICA (203 Czech Republic, belonging to the institution), Tomáš ROHAN (203 Czech Republic, belonging to the institution), Christophe LENGLET, Julien COHEN-ADAD, Petr HLUSTIK (203 Czech Republic), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Zdeněk KADAŇKA (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution)

Edition

European Journal of Neurology, Oxford, Rapid Science Ltd. 2021, 1351-5101

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.288

RIV identification code

RIV/00216224:14110/21:00120165

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/ene.15027

UT WoS

000680930200001

Keywords in English

diffusion magnetic resonance imaging; diffusion tensor imaging; spinal cord compression

Abstract

V originále

Background and purpose Non-myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible degenerative cervical myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) and electrophysiological measures assess compression severity and neurological dysfunction, respectively, underlying microstructural deficits still have to be established in NMDC and DCM patients. The study aims to establish tract-specific diffusion MRI markers of electrophysiological deficits to predict the progression of asymptomatic NMDC to symptomatic DCM. Methods High-resolution 3 T diffusion MRI was acquired for 103 NMDC and 21 DCM patients compared to 60 healthy controls to reveal diffusion alterations and relationships between tract-specific diffusion metrics and corresponding electrophysiological measures and compression severity. Relationship between the degree of DCM disability, assessed by the modified Japanese Orthopaedic Association scale, and tract-specific microstructural changes in DCM patients was also explored. Results The study identified diffusion-derived abnormalities in the gray matter, dorsal and lateral tracts congruent with trans-synaptic degeneration and demyelination in chronic degenerative spinal cord compression with more profound alterations in DCM than NMDC. Diffusion metrics were affected in the C3-6 area as well as above the compression level at C3 with more profound rostral deficits in DCM than NMDC. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked potentials, respectively, whereas electromyography outcomes corresponded with gray matter microstructure. DCM disability corresponded with microstructure alteration in lateral columns. Conclusions Outcomes imply the necessity of high-resolution tract-specific diffusion MRI for monitoring degenerative spinal pathology in longitudinal studies.

Links

LM2018140, research and development project

Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

NV18-04-00159, research and development project

Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministry of Health of the CR

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

VALOSEK, Jan, Rene LABOUNEK, Tomáš HORÁK, Magda HORÁKOVÁ, Petr BEDNAŘÍK, Miloš KEŘKOVSKÝ, Jan KOČICA, Tomáš ROHAN, Christophe LENGLET, Julien COHEN-ADAD, Petr HLUSTIK, Eva VLČKOVÁ, Zdeněk KADAŇKA, Josef BEDNAŘÍK and Alena SVÁTKOVÁ. Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression. European Journal of Neurology. Oxford: Rapid Science Ltd., 2021, vol. 28, No 11, p. 3784-3797. ISSN 1351-5101. Available from: https://dx.doi.org/10.1111/ene.15027.

@article{1804612,
   author = {Valosek, Jan and Labounek, Rene and Horák, Tomáš and Horáková, Magda and Bednařík, Petr and Keřkovský, Miloš and Kočica, Jan and Rohan, Tomáš and Lenglet, Christophe and CohenandAdad, Julien and Hlustik, Petr and Vlčková, Eva and Kadaňka, Zdeněk and Bednařík, Josef and Svátková, Alena},
   article_location = {Oxford},
   article_number = {11},
   doi = {http://dx.doi.org/10.1111/ene.15027},
   keywords = {diffusion magnetic resonance imaging; diffusion tensor imaging; spinal cord compression},
   language = {eng},
   issn = {1351-5101},
   journal = {European Journal of Neurology},
   title = {Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/ene.15027},
   volume = {28},
   year = {2021}
}

TY  - JOUR
ID  - 1804612
AU  - Valosek, Jan - Labounek, Rene - Horák, Tomáš - Horáková, Magda - Bednařík, Petr - Keřkovský, Miloš - Kočica, Jan - Rohan, Tomáš - Lenglet, Christophe - Cohen-Adad, Julien - Hlustik, Petr - Vlčková, Eva - Kadaňka, Zdeněk - Bednařík, Josef - Svátková, Alena
PY  - 2021
TI  - Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression
JF  - European Journal of Neurology
VL  - 28
IS  - 11
SP  - 3784-3797
EP  - 3784-3797
PB  - Rapid Science Ltd.
SN  - 13515101
KW  - diffusion magnetic resonance imaging
KW  - diffusion tensor imaging
KW  - spinal cord compression
UR  - https://onlinelibrary.wiley.com/doi/10.1111/ene.15027
N2  - Background and purpose Non-myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible degenerative cervical myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) and electrophysiological measures assess compression severity and neurological dysfunction, respectively, underlying microstructural deficits still have to be established in NMDC and DCM patients. The study aims to establish tract-specific diffusion MRI markers of electrophysiological deficits to predict the progression of asymptomatic NMDC to symptomatic DCM. Methods High-resolution 3 T diffusion MRI was acquired for 103 NMDC and 21 DCM patients compared to 60 healthy controls to reveal diffusion alterations and relationships between tract-specific diffusion metrics and corresponding electrophysiological measures and compression severity. Relationship between the degree of DCM disability, assessed by the modified Japanese Orthopaedic Association scale, and tract-specific microstructural changes in DCM patients was also explored. Results The study identified diffusion-derived abnormalities in the gray matter, dorsal and lateral tracts congruent with trans-synaptic degeneration and demyelination in chronic degenerative spinal cord compression with more profound alterations in DCM than NMDC. Diffusion metrics were affected in the C3-6 area as well as above the compression level at C3 with more profound rostral deficits in DCM than NMDC. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked potentials, respectively, whereas electromyography outcomes corresponded with gray matter microstructure. DCM disability corresponded with microstructure alteration in lateral columns. Conclusions Outcomes imply the necessity of high-resolution tract-specific diffusion MRI for monitoring degenerative spinal pathology in longitudinal studies.
ER  -

VALOSEK, Jan, Rene LABOUNEK, Tomáš HORÁK, Magda HORÁKOVÁ, Petr BEDNAŘÍK, Miloš KEŘKOVSKÝ, Jan KOČICA, Tomáš ROHAN, Christophe LENGLET, Julien COHEN-ADAD, Petr HLUSTIK, Eva VLČKOVÁ, Zdeněk KADAŇKA, Josef BEDNAŘÍK and Alena SVÁTKOVÁ. Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression. \textit{European Journal of Neurology}. Oxford: Rapid Science Ltd., 2021, vol.~28, No~11, p.~3784-3797. ISSN~1351-5101. Available from: https://dx.doi.org/10.1111/ene.15027.

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