In vivo Molecular Signatures of Cervical Spinal Cord Pathology
in Degenerative Compression

J 2021

In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression

HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA et. al.

Basic information

Original name

In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression

Authors

HORÁK, Tomáš (203 Czech Republic, belonging to the institution), Magda HORÁKOVÁ (203 Czech Republic, belonging to the institution), Alena SVÁTKOVÁ (703 Slovakia), Zdeněk KADAŇKA (203 Czech Republic, belonging to the institution), Petr KUDLIČKA (203 Czech Republic, belonging to the institution), Jan VALOSEK (203 Czech Republic), Tomáš ROHAN (203 Czech Republic), Miloš KEŘKOVSKÝ (203 Czech Republic), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Zdeněk KADAŇKA (203 Czech Republic), Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Petr BEDNAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neurotrauma, New Rochelle, Mary Ann Liebert, 2021, 0897-7151

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.869

RIV identification code

RIV/00216224:14110/21:00120166

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1089/neu.2021.0151

UT WoS

000745030000006

Keywords in English

cervical spinal cord; compression; degenerative magnetic resonance; myelopathy; spectroscopy

Abstract

V originále

Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and −14%) and SC (+12%, +46%, and −8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (−0.376 < r < −0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = −0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.

Links

NV18-04-00159, research and development project

Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministry of Health of the CR

90042, large research infrastructures

Name: CESNET II

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA, Jan VALOSEK, Tomáš ROHAN, Miloš KEŘKOVSKÝ, Eva VLČKOVÁ, Zdeněk KADAŇKA, Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK and Petr BEDNAŘÍK. In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression. Journal of Neurotrauma. New Rochelle: Mary Ann Liebert, 2021, vol. 38, No 21, p. 2999-3010. ISSN 0897-7151. Available from: https://dx.doi.org/10.1089/neu.2021.0151.

@article{1804614,
   author = {Horák, Tomáš and Horáková, Magda and Svátková, Alena and Kadaňka, Zdeněk and Kudlička, Petr and Valosek, Jan and Rohan, Tomáš and Keřkovský, Miloš and Vlčková, Eva and Kadaňka, Zdeněk and Deelchand, Dinesh K. and Henry, PierreandGilles and Bednařík, Josef and Bednařík, Petr},
   article_location = {New Rochelle},
   article_number = {21},
   doi = {http://dx.doi.org/10.1089/neu.2021.0151},
   keywords = {cervical spinal cord; compression; degenerative magnetic resonance; myelopathy; spectroscopy},
   language = {eng},
   issn = {0897-7151},
   journal = {Journal of Neurotrauma},
   title = {In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression},
   url = {https://www.liebertpub.com/doi/10.1089/neu.2021.0151},
   volume = {38},
   year = {2021}
}

TY  - JOUR
ID  - 1804614
AU  - Horák, Tomáš - Horáková, Magda - Svátková, Alena - Kadaňka, Zdeněk - Kudlička, Petr - Valosek, Jan - Rohan, Tomáš - Keřkovský, Miloš - Vlčková, Eva - Kadaňka, Zdeněk - Deelchand, Dinesh K. - Henry, Pierre-Gilles - Bednařík, Josef - Bednařík, Petr
PY  - 2021
TI  - In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression
JF  - Journal of Neurotrauma
VL  - 38
IS  - 21
SP  - 2999-3010
EP  - 2999-3010
PB  - Mary Ann Liebert
SN  - 08977151
KW  - cervical spinal cord
KW  - compression
KW  - degenerative magnetic resonance
KW  - myelopathy
KW  - spectroscopy
UR  - https://www.liebertpub.com/doi/10.1089/neu.2021.0151
N2  - Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and −14%) and SC (+12%, +46%, and −8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (−0.376 < r < −0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = −0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.
ER  -

HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA, Jan VALOSEK, Tomáš ROHAN, Miloš KEŘKOVSKÝ, Eva VLČKOVÁ, Zdeněk KADAŇKA, Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK and Petr BEDNAŘÍK. In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression. \textit{Journal of Neurotrauma}. New Rochelle: Mary Ann Liebert, 2021, vol.~38, No~21, p.~2999-3010. ISSN~0897-7151. Available from: https://dx.doi.org/10.1089/neu.2021.0151.

Detailed Information on Publication Record