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@article{1804614,
author = {Horák, Tomáš and Horáková, Magda and Svátková, Alena and Kadaňka, Zdeněk and Kudlička, Petr and Valosek, Jan and Rohan, Tomáš and Keřkovský, Miloš and Vlčková, Eva and Kadaňka, Zdeněk and Deelchand, Dinesh K. and Henry, PierreandGilles and Bednařík, Josef and Bednařík, Petr},
article_location = {New Rochelle},
article_number = {21},
doi = {http://dx.doi.org/10.1089/neu.2021.0151},
keywords = {cervical spinal cord; compression; degenerative magnetic resonance; myelopathy; spectroscopy},
language = {eng},
issn = {0897-7151},
journal = {Journal of Neurotrauma},
title = {In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression},
url = {https://www.liebertpub.com/doi/10.1089/neu.2021.0151},
volume = {38},
year = {2021}
}
TY - JOUR
ID - 1804614
AU - Horák, Tomáš - Horáková, Magda - Svátková, Alena - Kadaňka, Zdeněk - Kudlička, Petr - Valosek, Jan - Rohan, Tomáš - Keřkovský, Miloš - Vlčková, Eva - Kadaňka, Zdeněk - Deelchand, Dinesh K. - Henry, Pierre-Gilles - Bednařík, Josef - Bednařík, Petr
PY - 2021
TI - In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression
JF - Journal of Neurotrauma
VL - 38
IS - 21
SP - 2999-3010
EP - 2999-3010
PB - Mary Ann Liebert
SN - 08977151
KW - cervical spinal cord
KW - compression
KW - degenerative magnetic resonance
KW - myelopathy
KW - spectroscopy
UR - https://www.liebertpub.com/doi/10.1089/neu.2021.0151
N2 - Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and −14%) and SC (+12%, +46%, and −8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (−0.376 < r < −0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = −0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.
ER -
HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA, Jan VALOSEK, Tomáš ROHAN, Miloš KEŘKOVSKÝ, Eva VLČKOVÁ, Zdeněk KADAŇKA, Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK and Petr BEDNAŘÍK. In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression. \textit{Journal of Neurotrauma}. New Rochelle: Mary Ann Liebert, vol.~38, No~21, p.~2999-3010. ISSN~0897-7151. doi:10.1089/neu.2021.0151. 2021.
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