VESELÝ, Petr, Pavel BENEŠ, Petra ZÁDĚROVÁ and Jana SOKOLOVÁ ŠIDLOVÁ. Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka (Tear osmolarity, its measurement and correlation with other tests for dry eye examination). In Oftalmologický tematický kurz. 2021.
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Basic information
Original name Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka
Name in Czech Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka
Name (in English) Tear osmolarity, its measurement and correlation with other tests for dry eye examination
Authors VESELÝ, Petr (203 Czech Republic, guarantor, belonging to the institution), Pavel BENEŠ (203 Czech Republic), Petra ZÁDĚROVÁ (203 Czech Republic) and Jana SOKOLOVÁ ŠIDLOVÁ (203 Czech Republic).
Edition Oftalmologický tematický kurz, 2021.
Other information
Original language Czech
Type of outcome Requested lectures
Field of Study 30207 Ophthalmology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14110/21:00122910
Organization unit Faculty of Medicine
Keywords (in Czech) Tearlab;osmolarita;dotazník DEQ-5;syndrom suchého oka;Sjogrenův syndrom;break time test
Keywords in English Tearlab;osmolarity;DEQ-5 questionnaire;dry eye syndrome;Sjogren’s syndrome;break time test
Changed by Changed by: Mgr. Petr Veselý, DiS., Ph.D., učo 176573. Changed: 23/11/2021 10:47.
Abstract
Abstract Aim: To determine the values of osmolarity of tears of the right and left eye in individual probands, to evaluate their symptoms using the DEQ-5 questionnaire and to compare the results with other studies. Furthermore, to find out how invasive and non-invasive methods of tear film quality evaluation correlate together. Methods: In our study, we had data from 20 probands, whose average age was 23.5 years (SD 1.55 years). All subjects underwent a standard optometric examination, including the determination of the current subjective correction of the refractive error. Subsequently, we presented the DEQ-5 questionnaire to the probands. After completing the questionnaires, each proband underwent tear osmolarity using a TearLab® instrument (TearLab Corporation, USA). Further examination was performed on a Keratograph 5M® (Oculus, Germany). Results: The average value of tear osmolarity in the right and left eye of all probands was 300.35 (SD 16.52) and 293.70 (SD 12.92) mOsmol/l, respectively. The difference in the osmolarity of both eyes in one proband greater than 8 mOsmol/l inclusive was identified in a total of 11 probands out of 20 (i.e. 55 %). The mean value of the non-invasive break time test (nBUT) on the right and left eyes of all probands was 14.05 s (SD 5.78 s) and 15.59 s (SD 6.13 s), respectively. From the DEQ-5 questionnaire, we recorded a positive capture (score equal to greater than 6 points) in a total of 8 probands out of 20 (i.e. 40 %). Conclusion: The results of our study show that there is no correlation between non-invasive break time test (nBUT) and tear osmolarity (difTL8, R = 0.23 at p = 0.32). To evaluate the symptoms of dry eye disease, a special questionnaire with 5 questions (Dry Eye Questionnaire, DEQ-5) proved to be very accurate and effective, which helped us to accurately divide the baseline group into a symptomatic group and a group without symptoms (p <0.001). Subsequently, we demonstrated statistically significant sensitivity and specificity in both tests (nBUT, difTL8).
Abstract (in English)
Abstract Aim: To determine the values of osmolarity of tears of the right and left eye in individual probands, to evaluate their symptoms using the DEQ-5 questionnaire and to compare the results with other studies. Furthermore, to find out how invasive and non-invasive methods of tear film quality evaluation correlate together. Methods: In our study, we had data from 20 probands, whose average age was 23.5 years (SD 1.55 years). All subjects underwent a standard optometric examination, including the determination of the current subjective correction of the refractive error. Subsequently, we presented the DEQ-5 questionnaire to the probands. After completing the questionnaires, each proband underwent tear osmolarity using a TearLab® instrument (TearLab Corporation, USA). Further examination was performed on a Keratograph 5M® (Oculus, Germany). Results: The average value of tear osmolarity in the right and left eye of all probands was 300.35 (SD 16.52) and 293.70 (SD 12.92) mOsmol/l, respectively. The difference in the osmolarity of both eyes in one proband greater than 8 mOsmol/l inclusive was identified in a total of 11 probands out of 20 (i.e. 55 %). The mean value of the non-invasive break time test (nBUT) on the right and left eyes of all probands was 14.05 s (SD 5.78 s) and 15.59 s (SD 6.13 s), respectively. From the DEQ-5 questionnaire, we recorded a positive capture (score equal to greater than 6 points) in a total of 8 probands out of 20 (i.e. 40 %). Conclusion: The results of our study show that there is no correlation between non-invasive break time test (nBUT) and tear osmolarity (difTL8, R = 0.23 at p = 0.32). To evaluate the symptoms of dry eye disease, a special questionnaire with 5 questions (Dry Eye Questionnaire, DEQ-5) proved to be very accurate and effective, which helped us to accurately divide the baseline group into a symptomatic group and a group without symptoms (p <0.001). Subsequently, we demonstrated statistically significant sensitivity and specificity in both tests (nBUT, difTL8).
Links
MUNI/11/0993/2020, interní kód MUName: Stanovení fyziologických hodnot osmolarity pomocí zařízení TearLab a korelace těchto hodnot s dalšími neinvazivními testy slzného filmu (Acronym: TEFILOM)
Investor: Masaryk University
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