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@article{1805161, author = {Holická, Martina and Vysloužil, Jakub and Kubová, Kateřina and Muselík, Jan and Vetchý, David}, article_location = {Praha}, article_number = {10}, keywords = {GnRH analogues; GnRH agonist; GnRH antagonist; hormones; therapy}, language = {cze}, issn = {0009-2770}, journal = {CHEMICKÉ LISTY}, title = {Gonadoliberin (gonadotropin uvolňující hormon), jeho agonisté a antagonisté}, url = {http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3933/3844}, volume = {115}, year = {2021} }
TY - JOUR ID - 1805161 AU - Holická, Martina - Vysloužil, Jakub - Kubová, Kateřina - Muselík, Jan - Vetchý, David PY - 2021 TI - Gonadoliberin (gonadotropin uvolňující hormon), jeho agonisté a antagonisté JF - CHEMICKÉ LISTY VL - 115 IS - 10 SP - 516-523 EP - 516-523 PB - CHEMICKE LISTY SN - 00092770 KW - GnRH analogues KW - GnRH agonist KW - GnRH antagonist KW - hormones KW - therapy UR - http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3933/3844 N2 - Nowadays, analogues of gonadotropin-releasing hormone are among the standard drugs in several indications, often using modern dosage forms. Globally, their market is estimated at billions of $ annually. This review article summarizes basic information on the relationship between structure and effect, pharmacology, and application of gonadotropin-releasing hormone and its synthetic analogues. Due to their properties, namely a higher efficiency and a higher binding affinity for the gonadotropinreleasing hormone receptor compared to native gonadotropin releasing hormone, the analogues have found applications in the treatment of many diseases, where it is necessary to suppress the secretion of gonadotropins and sex hormones. They are usually indicated for the treatment of cancers of various origins, premature puberty or artificial insemination. Due to their peptide nature, they are not administered orally, but require injection or intranasal administration. Compared to agonists, antagonists show faster onset of action and the absence of the so-called flareup phenomenon, i.e., temporarily increased serum levels of lutropin, follitropin and, consequently, of testosterone and estradiol. ER -
HOLICKÁ, Martina, Jakub VYSLOUŽIL, Kateřina KUBOVÁ, Jan MUSELÍK a David VETCHÝ. Gonadoliberin (gonadotropin uvolňující hormon), jeho agonisté a antagonisté. \textit{CHEMICKÉ LISTY}. Praha: CHEMICKE LISTY, 2021, roč.~115, č.~10, s.~516-523. ISSN~0009-2770.
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