Supramolecular hydrogelation via host-guest anion recognition:
Lamellar hydrogel materials for the release of cationic cargo

J 2021

Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo

KOKAN, Zoran, Miroslava DUSKOVA-SMRCKOVA and Vladimír ŠINDELÁŘ

Basic information

Original name

Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo

Authors

KOKAN, Zoran (191 Croatia, belonging to the institution), Miroslava DUSKOVA-SMRCKOVA (203 Czech Republic) and Vladimír ŠINDELÁŘ (203 Czech Republic, guarantor, belonging to the institution)

Edition

CHEM, CAMBRIDGE, CELL PRESS, 2021, 2451-9294

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10400 1.4 Chemical sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 25.832

RIV identification code

RIV/00216224:14310/21:00123019

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.chempr.2021.06.024

UT WoS

000695415900017

Keywords in English

MOLECULAR-WEIGHT; GELS; WATER; POLYMER; BINDING; MACROCYCLE; BAMBUSURIL; RHEOLOGY; DELIVERY; GELATORS

Abstract

V originále

Hydrogelation triggered by host-guest anion recognition is difficult to achieve due to the challenging anion recognition in water and de novo gelator design. Herein, we report such a hydrogel system, based on bambus[6]uril anion receptor, BU. Albeit not a gelator per se, BU formed hydrogels selectively in the presence of iodides or perchlorates. Anion recognition by BU governed the hydrogelation, indicated by the NMR, ATR-IR, and single-crystal X-ray. Gelation mechanism and lamellar nature of the network structure were elucidated by SAXS, cryoSEM, and holotomography methods. Rheological characterization revealed the hydrogels were stable and relatively strong. In physiological saline solutions, the hydrogels released cationic cargo by cation metathesis, leading to a gel-to-gel transformation. Choline derivatives, as model drugs, exhibited slow release from the hydrogels. Our simple hydrogel system may inspire the design of smart materials based on host-guest anion recognition, where the release or sequestration of specific charged species are desirable.

Links

EF16_027/0008360, research and development project

Name: Postdoc@MUNI

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Citovat

KOKAN, Zoran, Miroslava DUSKOVA-SMRCKOVA and Vladimír ŠINDELÁŘ. Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo. CHEM. CAMBRIDGE: CELL PRESS, 2021, vol. 7, No 9, p. 2473-2490. ISSN 2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2021.06.024.

@article{1805315,
   author = {Kokan, Zoran and DuskovaandSmrckova, Miroslava and Šindelář, Vladimír},
   article_location = {CAMBRIDGE},
   article_number = {9},
   doi = {http://dx.doi.org/10.1016/j.chempr.2021.06.024},
   keywords = {MOLECULAR-WEIGHT; GELS; WATER; POLYMER; BINDING; MACROCYCLE; BAMBUSURIL; RHEOLOGY; DELIVERY; GELATORS},
   language = {eng},
   issn = {2451-9294},
   journal = {CHEM},
   title = {Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S2451929421003569?via%3Dihub},
   volume = {7},
   year = {2021}
}

TY  - JOUR
ID  - 1805315
AU  - Kokan, Zoran - Duskova-Smrckova, Miroslava - Šindelář, Vladimír
PY  - 2021
TI  - Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo
JF  - CHEM
VL  - 7
IS  - 9
SP  - 2473-2490
EP  - 2473-2490
PB  - CELL PRESS
SN  - 24519294
KW  - MOLECULAR-WEIGHT
KW  - GELS
KW  - WATER
KW  - POLYMER
KW  - BINDING
KW  - MACROCYCLE
KW  - BAMBUSURIL
KW  - RHEOLOGY
KW  - DELIVERY
KW  - GELATORS
UR  - https://www.sciencedirect.com/science/article/abs/pii/S2451929421003569?via%3Dihub
N2  - Hydrogelation triggered by host-guest anion recognition is difficult to achieve due to the challenging anion recognition in water and de novo gelator design. Herein, we report such a hydrogel system, based on bambus[6]uril anion receptor, BU. Albeit not a gelator per se, BU formed hydrogels selectively in the presence of iodides or perchlorates. Anion recognition by BU governed the hydrogelation, indicated by the NMR, ATR-IR, and single-crystal X-ray. Gelation mechanism and lamellar nature of the network structure were elucidated by SAXS, cryoSEM, and holotomography methods. Rheological characterization revealed the hydrogels were stable and relatively strong. In physiological saline solutions, the hydrogels released cationic cargo by cation metathesis, leading to a gel-to-gel transformation. Choline derivatives, as model drugs, exhibited slow release from the hydrogels. Our simple hydrogel system may inspire the design of smart materials based on host-guest anion recognition, where the release or sequestration of specific charged species are desirable.
ER  -

KOKAN, Zoran, Miroslava DUSKOVA-SMRCKOVA and Vladimír ŠINDELÁŘ. Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo. \textit{CHEM}. CAMBRIDGE: CELL PRESS, 2021, vol.~7, No~9, p.~2473-2490. ISSN~2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2021.06.024.

Detailed Information on Publication Record