Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo

KOKAN, Zoran, Miroslava DUSKOVA-SMRCKOVA and Vladimír ŠINDELÁŘ. Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo. CHEM. CAMBRIDGE: CELL PRESS, 2021, vol. 7, No 9, p. 2473-2490. ISSN 2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2021.06.024.

Basic information

• Original name: Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo
• Authors: KOKAN, Zoran (191 Croatia, belonging to the institution), Miroslava DUSKOVA-SMRCKOVA (203 Czech Republic) and Vladimír ŠINDELÁŘ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: CHEM, CAMBRIDGE, CELL PRESS, 2021, 2451-9294.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10400 1.4 Chemical sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 25.832
• RIV identification code: RIV/00216224:14310/21:00123019
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.chempr.2021.06.024
• UT WoS: 000695415900017
• Keywords in English: MOLECULAR-WEIGHT; GELS; WATER; POLYMER; BINDING; MACROCYCLE; BAMBUSURIL; RHEOLOGY; DELIVERY; GELATORS
• Tags: CF SAXS, rivok
• Tags: International impact, Reviewed

Abstract

Hydrogelation triggered by host-guest anion recognition is difficult to achieve due to the challenging anion recognition in water and de novo gelator design. Herein, we report such a hydrogel system, based on bambus[6]uril anion receptor, BU. Albeit not a gelator per se, BU formed hydrogels selectively in the presence of iodides or perchlorates. Anion recognition by BU governed the hydrogelation, indicated by the NMR, ATR-IR, and single-crystal X-ray. Gelation mechanism and lamellar nature of the network structure were elucidated by SAXS, cryoSEM, and holotomography methods. Rheological characterization revealed the hydrogels were stable and relatively strong. In physiological saline solutions, the hydrogels released cationic cargo by cation metathesis, leading to a gel-to-gel transformation. Choline derivatives, as model drugs, exhibited slow release from the hydrogels. Our simple hydrogel system may inspire the design of smart materials based on host-guest anion recognition, where the release or sequestration of specific charged species are desirable.

Links

• EF16_027/0008360, research and development project: Name: Postdoc@MUNI
• EF17_043/0009632, research and development project: Name: CETOCOEN Excellence
• LM2018121, research and development project: Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

• LM2018127, research and development project: Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

• 857560, interní kód MU(CEP code: EF17_043/0009632): Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation