Hide-and-Seek: A Game Played between Parasitic Protists and
Their Hosts

J 2021

Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts

KOLÁŘOVÁ, Iva and Andrea BARDŮNEK VALIGUROVÁ

Basic information

Original name

Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts

Authors

KOLÁŘOVÁ, Iva (203 Czech Republic) and Andrea BARDŮNEK VALIGUROVÁ (703 Slovakia, guarantor, belonging to the institution)

Edition

Microorganisms, Basel, MDPI, 2021, 2076-2607

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10613 Zoology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.926

RIV identification code

RIV/00216224:14310/21:00119377

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.3390/microorganisms9122434

UT WoS

000735501200001

Keywords in English

unicellular parasite; parasitic protist; Cryptosporidium; Leishmania; intracellular; epicellular; extracellular; parasitophorous sac; parasitophorous vacuole; adaptation to parasitism; evasion strategies; host defence

Abstract

V originále

After invading the host organism, a battle occurs between the parasitic protists and the host’s immune system, the result of which determines not only whether and how well the host survives and recovers, but also the fate of the parasite itself. The exact weaponry of this battle depends, among others, on the parasite localisation. While some parasitic protists do not invade the host cell at all (extracellular parasites), others have developed successful intracellular lifestyles (intracellular parasites) or attack only the surface of the host cell (epicellular parasites). Epicellular and intracellular protist parasites have developed various mechanisms to hijack host cell functions to escape cellular defences and immune responses, and, finally, to gain access to host nutrients. They use various evasion tactics to secure the tight contact with the host cell and the direct nutrient supply. This review focuses on the adaptations and evasion strategies of parasitic protists on the example of two very successful parasites of medical significance, Cryptosporidium and Leishmania, while discussing different localisation (epicellular vs. intracellular) with respect to the host cell.

Links

GBP505/12/G112, research and development project

Name: ECIP - Evropské centrum ichtyoparazitologie

Investor: Czech Science Foundation

GPP506/10/P372, research and development project

Name: Srovnávací morfologie a imunohistochemie v hodnocení fylogenetických vztahů mezi zástupci raných linií kmene Apicomplexa

Investor: Czech Science Foundation

Citovat

KOLÁŘOVÁ, Iva and Andrea BARDŮNEK VALIGUROVÁ. Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts. Microorganisms. Basel: MDPI, 2021, vol. 9, No 12, p. 2434-2455. ISSN 2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms9122434.

@article{1806099,
   author = {Kolářová, Iva and Bardůnek Valigurová, Andrea},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/microorganisms9122434},
   keywords = {unicellular parasite; parasitic protist; Cryptosporidium; Leishmania; intracellular; epicellular; extracellular; parasitophorous sac; parasitophorous vacuole; adaptation to parasitism; evasion strategies; host defence},
   language = {eng},
   issn = {2076-2607},
   journal = {Microorganisms},
   title = {Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts},
   url = {https://doi.org/10.3390/microorganisms9122434},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1806099
AU  - Kolářová, Iva - Bardůnek Valigurová, Andrea
PY  - 2021
TI  - Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts
JF  - Microorganisms
VL  - 9
IS  - 12
SP  - 2434
EP  - 2434
PB  - MDPI
SN  - 20762607
KW  - unicellular parasite
KW  - parasitic protist
KW  - Cryptosporidium
KW  - Leishmania
KW  - intracellular
KW  - epicellular
KW  - extracellular
KW  - parasitophorous sac
KW  - parasitophorous vacuole
KW  - adaptation to parasitism
KW  - evasion strategies
KW  - host defence
UR  - https://doi.org/10.3390/microorganisms9122434
N2  - After invading the host organism, a battle occurs between the parasitic protists and the host’s immune system, the result of which determines not only whether and how well the host survives and recovers, but also the fate of the parasite itself. The exact weaponry of this battle depends, among others, on the parasite localisation. While some parasitic protists do not invade the host cell at all (extracellular parasites), others have developed successful intracellular lifestyles (intracellular parasites) or attack only the surface of the host cell (epicellular parasites). Epicellular and intracellular protist parasites have developed various mechanisms to hijack host cell functions to escape cellular defences and immune responses, and, finally, to gain access to host nutrients. They use various evasion tactics to secure the tight contact with the host cell and the direct nutrient supply. This review focuses on the adaptations and evasion strategies of parasitic protists on the example of two very successful parasites of medical significance, Cryptosporidium and Leishmania, while discussing different localisation (epicellular vs. intracellular) with respect to the host cell.
ER  -

KOLÁŘOVÁ, Iva and Andrea BARDŮNEK VALIGUROVÁ. Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts. \textit{Microorganisms}. Basel: MDPI, 2021, vol.~9, No~12, p.~2434-2455. ISSN~2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms9122434.

Detailed Information on Publication Record