| MOSEJOVÁ, Eva, Rebeka BOSNJAKOVIC, Lukáš KUBALA and Ondřej VAŠÍČEK. Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells. Antioxidants. Basel: MDPI, 2021, vol. 10, No 10, p. 1-16. ISSN 2076-3921. Available from: https://dx.doi.org/10.3390/antiox10101576. |
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@article{1806136,
author = {Mosejová, Eva and Bosnjakovic, Rebeka and Kubala, Lukáš and Vašíček, Ondřej},
article_location = {Basel},
article_number = {10},
doi = {http://dx.doi.org/10.3390/antiox10101576},
keywords = {pseurotin D; proliferation; apoptosis; mitochondrial activity; reactive oxygen species; lymphoma},
language = {eng},
issn = {2076-3921},
journal = {Antioxidants},
title = {Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells},
url = {https://www.mdpi.com/2076-3921/10/10/1576},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1806136
AU - Mosejová, Eva - Bosnjakovic, Rebeka - Kubala, Lukáš - Vašíček, Ondřej
PY - 2021
TI - Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells
JF - Antioxidants
VL - 10
IS - 10
SP - 1-16
EP - 1-16
PB - MDPI
SN - 20763921
KW - pseurotin D
KW - proliferation
KW - apoptosis
KW - mitochondrial activity
KW - reactive oxygen species
KW - lymphoma
UR - https://www.mdpi.com/2076-3921/10/10/1576
N2 - Chronic lymphocytic leukemia (CLL) is the most prevalent lymphoid malignancy in many geographical regions of the world. Pseurotin D, a secondary metabolite of fungi, represents a group of bioactive natural products with a newly ascribed range of interesting biological activities. The purpose of this study was to bring new insights into the mechanism behind the effects of pseurotin D on MEC-1 cells as a representative CLL cell line, with a particular focus on selected signaling pathways important in the proliferation of cells and targeting mitochondrial metabolism. Our results showed that pseurotin D was able to significantly inhibit the proliferation of MEC-1 cells and arrested them in the G2/M cell cycle phase. In addition, pseurotin D was able to induce apoptosis. We found that all of these effects were associated with a change in mitochondrial membrane potential and the production of mitochondrial reactive oxygen species (ROS). We showed for the first time that pseurotin D suppresses MEC-1 cell proliferation and induces apoptotic cell death via induction of the collapse of the mitochondria respiratory chain and the ROS-related caspase pathway. Our results show the pseurotins family as promising compounds which could serve as a basis for the development of new compounds in the treatment of lymphoma.
ER -
MOSEJOVÁ, Eva, Rebeka BOSNJAKOVIC, Lukáš KUBALA and Ondřej VAŠÍČEK. Pseurotin D Induces Apoptosis through Targeting Redox Sensitive Pathways in Human Lymphoid Leukemia Cells. \textit{Antioxidants}. Basel: MDPI, 2021, vol.~10, No~10, p.~1-16. ISSN~2076-3921. Available from: https://dx.doi.org/10.3390/antiox10101576.
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