| SELINGEROVÁ, Iveta, Dalibor VALÍK, Lenka GESCHEIDTOVÁ, Vladimír ŠRÁMEK, Z. CERMAKOVA a Lenka ZDRAŽILOVÁ DUBSKÁ. Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI. Journal of Medical Virology. Hoboken: Wiley, 2021, roč. 93, č. 3, s. 1805-1809. ISSN 0146-6615. Dostupné z: https://dx.doi.org/10.1002/jmv.26612. |
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@article{1807083,
author = {Selingerová, Iveta and Valík, Dalibor and Gescheidtová, Lenka and Šrámek, Vladimír and Cermakova, Z. and Zdražilová Dubská, Lenka},
article_location = {Hoboken},
article_number = {3},
doi = {http://dx.doi.org/10.1002/jmv.26612},
keywords = {anti‐ SARS‐ CoV‐ 2 IgG; anti‐ SARS‐ CoV‐ 2 IgM; CLIA; inter‐ assay batch variation; interpretative inconsistency},
language = {eng},
issn = {0146-6615},
journal = {Journal of Medical Virology},
note = {Bez afiliace k MU.},
title = {Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI},
url = {https://onlinelibrary.wiley.com/doi/10.1002/jmv.26612},
volume = {93},
year = {2021}
}
TY - JOUR
ID - 1807083
AU - Selingerová, Iveta - Valík, Dalibor - Gescheidtová, Lenka - Šrámek, Vladimír - Cermakova, Z. - Zdražilová Dubská, Lenka
PY - 2021
TI - Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI
JF - Journal of Medical Virology
VL - 93
IS - 3
SP - 1805-1809
EP - 1805-1809
PB - Wiley
SN - 01466615
N1 - Bez afiliace k MU.
KW - anti‐ SARS‐ CoV‐ 2 IgG
KW - anti‐ SARS‐ CoV‐ 2 IgM
KW - CLIA
KW - inter‐ assay batch variation
KW - interpretative inconsistency
UR - https://onlinelibrary.wiley.com/doi/10.1002/jmv.26612
N2 - Plasma specimens from coronavirus disease 2019 patients were double-tested for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies by two different batches of MAGLUMI 2019-nCov immunoglobulin M/immunoglobulin G (IgM/IgG) assays to evaluate IgM/IgG levels, qualitative interpretation, antibody kinetics, and linearity of diluted specimen. Here we show that (i) high-level IgM specimens need to be diluted with negative human plasma but not kit diluents and (ii) measured anti-SARS-CoV-2 IgM/IgG concentrations are substantially higher with later marketed immunoassay batch leading to (iii) the change of qualitative interpretation (positive vs. negative) in 12.3% of specimens measured for IgM, (iv) the informative time-course pattern of antibody production only when data from different immunoassay batches are not combined.
ER -
SELINGEROVÁ, Iveta, Dalibor VALÍK, Lenka GESCHEIDTOVÁ, Vladimír ŠRÁMEK, Z. CERMAKOVA a Lenka ZDRAŽILOVÁ DUBSKÁ. Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI. \textit{Journal of Medical Virology}. Hoboken: Wiley, 2021, roč.~93, č.~3, s.~1805-1809. ISSN~0146-6615. Dostupné z: https://dx.doi.org/10.1002/jmv.26612.
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