The emergence of the Coronavirus disease (COVID-19) pandemic caused by the SARS-CoV-2 virus has had a widespread public health impact, thus causing a significant socioeconomic burden. Since it was first identified in Wuhan, China, in 2019, it has rapidly spread around the world, with several million reported cases to date. Consequences on the neurologist’s professional life have been heavy and persistent, starting from new puzzling clinical challenges up to the use of new tools through social media and telemedicine.