Penis as a primary site of an extraskeletal Ewing sarcoma A
case report

J 2021

Penis as a primary site of an extraskeletal Ewing sarcoma A case report

ADÁMKOVÁ KRÁKOROVÁ, Dagmar, Jana HALÁMKOVÁ, Štěpán TUČEK, Ondřej BÍLEK, Jan KRISTEK et. al.

Basic information

Original name

Penis as a primary site of an extraskeletal Ewing sarcoma A case report

Authors

ADÁMKOVÁ KRÁKOROVÁ, Dagmar (203 Czech Republic), Jana HALÁMKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Štěpán TUČEK (203 Czech Republic, belonging to the institution), Ondřej BÍLEK (203 Czech Republic, belonging to the institution), Jan KRISTEK (203 Czech Republic), Tomáš KAZDA (203 Czech Republic, belonging to the institution), Iva ZAMBO (203 Czech Republic, belonging to the institution), Regina DEMLOVÁ (203 Czech Republic, belonging to the institution) and Igor KISS (203 Czech Republic, belonging to the institution)

Edition

Medicine, Philadelphia, Lippincott Williams & Wilkins, 2021, 0025-7974

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.817

RIV identification code

RIV/00216224:14110/21:00120171

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1097/MD.0000000000025074

UT WoS

000659055900064

Keywords (in Czech)

extraskeletal Ewing sarcoma; multidisciplinary treatment; penis

Keywords in English

extraskeletal Ewing sarcoma; multidisciplinary treatment; penis

Abstract

V originále

Rationale: The Ewing sarcoma family of malignant tumors is a group of tumors characterized by morphologically similar round-cell neoplasms and by the presence of a common chromosomal translocation; Ewing sarcoma family of tumors typically occur in children and young adults between 4 to 15 years of age. The primary tumor usually originates in the bone, extraskeletal localization is rare. Patient concern: We present a case report concerning a 32-year-old male patient with a primary involvement of the penis. Diagnosis: The histopathology from the first penile biopsy showed a small-cell neuroendocrine carcinoma; however, that result was based on a sample obtained at a different facility than the Sarcoma Center, where the investigating pathologist did not have the adequate expertise. The patient then underwent a radical penectomy and a second reading of the histology was demanded after a radical penile amputation when Ewing sarcoma with R1 resection was confirmed. Interventions: The patient was referred to the national Sarcoma Center, where - using a multidisciplinary approach - the treatment was started with curative intent. However, it was preceded by a non-standard initiation of the therapy due to the poor primary diagnosis. Outcomes: The non-standard therapy at the onset of the disease caused a poor prognosis of an otherwise curable diagnosis. Despite all that, the patient survived for a relatively long time. Lessons: The treatment of sarcomas with atypical localizations should be conducted by an experienced multidisciplinary team in a center with experience in sarcoma treatment.

Links

NV18-07-00073, research and development project

Name: c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

Investor: Ministry of Health of the CR

90128, large research infrastructures

Name: CZECRIN III

Citovat

ADÁMKOVÁ KRÁKOROVÁ, Dagmar, Jana HALÁMKOVÁ, Štěpán TUČEK, Ondřej BÍLEK, Jan KRISTEK, Tomáš KAZDA, Iva ZAMBO, Regina DEMLOVÁ and Igor KISS. Penis as a primary site of an extraskeletal Ewing sarcoma A case report. Medicine. Philadelphia: Lippincott Williams & Wilkins, 2021, vol. 100, No 11, p. 1-5. ISSN 0025-7974. Available from: https://dx.doi.org/10.1097/MD.0000000000025074.

@article{1807088,
   author = {Adámková Krákorová, Dagmar and Halámková, Jana and Tuček, Štěpán and Bílek, Ondřej and Kristek, Jan and Kazda, Tomáš and Zambo, Iva and Demlová, Regina and Kiss, Igor},
   article_location = {Philadelphia},
   article_number = {11},
   doi = {http://dx.doi.org/10.1097/MD.0000000000025074},
   keywords = {extraskeletal Ewing sarcoma; multidisciplinary treatment; penis},
   language = {eng},
   issn = {0025-7974},
   journal = {Medicine},
   title = {Penis as a primary site of an extraskeletal Ewing sarcoma A case report},
   url = {https://journals.lww.com/md-journal/Fulltext/2021/03190/Penis_as_a_primary_site_of_an_extraskeletal_Ewing.64.aspx},
   volume = {100},
   year = {2021}
}

TY  - JOUR
ID  - 1807088
AU  - Adámková Krákorová, Dagmar - Halámková, Jana - Tuček, Štěpán - Bílek, Ondřej - Kristek, Jan - Kazda, Tomáš - Zambo, Iva - Demlová, Regina - Kiss, Igor
PY  - 2021
TI  - Penis as a primary site of an extraskeletal Ewing sarcoma A case report
JF  - Medicine
VL  - 100
IS  - 11
SP  - 1-5
EP  - 1-5
PB  - Lippincott Williams & Wilkins
SN  - 00257974
KW  - extraskeletal Ewing sarcoma
KW  - multidisciplinary treatment
KW  - penis
UR  - https://journals.lww.com/md-journal/Fulltext/2021/03190/Penis_as_a_primary_site_of_an_extraskeletal_Ewing.64.aspx
N2  - Rationale: The Ewing sarcoma family of malignant tumors is a group of tumors characterized by morphologically similar round-cell neoplasms and by the presence of a common chromosomal translocation; Ewing sarcoma family of tumors typically occur in children and young adults between 4 to 15 years of age. The primary tumor usually originates in the bone, extraskeletal localization is rare. Patient concern: We present a case report concerning a 32-year-old male patient with a primary involvement of the penis. Diagnosis: The histopathology from the first penile biopsy showed a small-cell neuroendocrine carcinoma; however, that result was based on a sample obtained at a different facility than the Sarcoma Center, where the investigating pathologist did not have the adequate expertise. The patient then underwent a radical penectomy and a second reading of the histology was demanded after a radical penile amputation when Ewing sarcoma with R1 resection was confirmed. Interventions: The patient was referred to the national Sarcoma Center, where - using a multidisciplinary approach - the treatment was started with curative intent. However, it was preceded by a non-standard initiation of the therapy due to the poor primary diagnosis. Outcomes: The non-standard therapy at the onset of the disease caused a poor prognosis of an otherwise curable diagnosis. Despite all that, the patient survived for a relatively long time. Lessons: The treatment of sarcomas with atypical localizations should be conducted by an experienced multidisciplinary team in a center with experience in sarcoma treatment.
ER  -

ADÁMKOVÁ KRÁKOROVÁ, Dagmar, Jana HALÁMKOVÁ, Štěpán TUČEK, Ondřej BÍLEK, Jan KRISTEK, Tomáš KAZDA, Iva ZAMBO, Regina DEMLOVÁ and Igor KISS. Penis as a primary site of an extraskeletal Ewing sarcoma A case report. \textit{Medicine}. Philadelphia: Lippincott Williams \&{} Wilkins, 2021, vol.~100, No~11, p.~1-5. ISSN~0025-7974. Available from: https://dx.doi.org/10.1097/MD.0000000000025074.

Detailed Information on Publication Record