Overview of the Mechanisms of Action of Selected Bisphenols and
Perfluoroalkyl Chemicals on the Male Reproductive Axes

J 2021

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

JEŠETA, Michal; Jana NAVRÁTILOVÁ; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Bartozs KEMPISTY et. al.

Základní údaje

Originální název

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

Autoři

JEŠETA, Michal; Jana NAVRÁTILOVÁ; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Bartozs KEMPISTY; Pavel VENTRUBA; Jana ŽÁKOVÁ a Igor CRHA

Vydání

Frontiers in Genetics, Laussane, FRONTIERS MEDIA SA, 2021, 1664-8021

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10603 Genetics and heredity

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.772

Kód RIV

RIV/00216224:14110/21:00120172

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3389/fgene.2021.692897

UT WoS

000717298400001

EID Scopus

2-s2.0-85116871312

Klíčová slova anglicky

male infertility; spermatogenesis; steroidogenesis; endocrine disrupting chemicals; bisphenol; spermatozoa; perfluoroalkyl substances

Štítky

14110411, 14110611, 143180, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2025 08:32, Mgr. Tereza Miškechová

Anotace

V originále

Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men's fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

EF19_074/0012727, projekt VaV

Název: MSCAfellow3@MUNI

NV18-08-00412, projekt VaV

Název: Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

Investor: Ministerstvo zdravotnictví ČR, Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

JEŠETA, Michal; Jana NAVRÁTILOVÁ; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Bartozs KEMPISTY; Pavel VENTRUBA; Jana ŽÁKOVÁ a Igor CRHA. Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes. Frontiers in Genetics. Laussane: FRONTIERS MEDIA SA, 2021, roč. 12, September 2021, s. 1-13. ISSN 1664-8021. Dostupné z: https://doi.org/10.3389/fgene.2021.692897.

@article{1807758,
   author = {Ješeta, Michal and Navrátilová, Jana and Franzová, Kateřina and Fialková, Sandra and Kempisty, Bartozs and Ventruba, Pavel and Žáková, Jana and Crha, Igor},
   article_location = {Laussane},
   article_number = {September 2021},
   doi = {https://doi.org/10.3389/fgene.2021.692897},
   keywords = {male infertility; spermatogenesis; steroidogenesis; endocrine disrupting chemicals; bisphenol; spermatozoa; perfluoroalkyl substances},
   language = {eng},
   issn = {1664-8021},
   journal = {Frontiers in Genetics},
   title = {Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes},
   url = {https://www.frontiersin.org/articles/10.3389/fgene.2021.692897/full},
   volume = {12},
   year = {2021}
}

TY  - JOUR
ID  - 1807758
AU  - Ješeta, Michal - Navrátilová, Jana - Franzová, Kateřina - Fialková, Sandra - Kempisty, Bartozs - Ventruba, Pavel - Žáková, Jana - Crha, Igor
PY  - 2021
TI  - Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes
JF  - Frontiers in Genetics
VL  - 12
IS  - September 2021
SP  - 1-13
EP  - 1-13
PB  - FRONTIERS MEDIA SA
SN  - 16648021
KW  - male infertility
KW  - spermatogenesis
KW  - steroidogenesis
KW  - endocrine disrupting chemicals
KW  - bisphenol
KW  - spermatozoa
KW  - perfluoroalkyl substances
UR  - https://www.frontiersin.org/articles/10.3389/fgene.2021.692897/full
N2  - Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men's fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.

ER -

JEŠETA, Michal; Jana NAVRÁTILOVÁ; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Bartozs KEMPISTY; Pavel VENTRUBA; Jana ŽÁKOVÁ a Igor CRHA. Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes. \textit{Frontiers in Genetics}. Laussane: FRONTIERS MEDIA SA, 2021, roč.~12, September 2021, s.~1-13. ISSN~1664-8021. Dostupné z: https://doi.org/10.3389/fgene.2021.692897.

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