Overview of the Mechanisms of Action of Selected Bisphenols and
Perfluoroalkyl Chemicals on the Male Reproductive Axes

J 2021

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

JEŠETA, Michal, Jana NAVRÁTILOVÁ, Kateřina FRANZOVÁ, Sandra FIALKOVÁ, Bartozs KEMPISTY et. al.

Basic information

Original name

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

Authors

JEŠETA, Michal (203 Czech Republic, guarantor, belonging to the institution), Jana NAVRÁTILOVÁ (203 Czech Republic, belonging to the institution), Kateřina FRANZOVÁ (203 Czech Republic, belonging to the institution), Sandra FIALKOVÁ (703 Slovakia, belonging to the institution), Bartozs KEMPISTY (616 Poland), Pavel VENTRUBA (203 Czech Republic, belonging to the institution), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution) and Igor CRHA (203 Czech Republic, belonging to the institution)

Edition

Frontiers in Genetics, Laussane, FRONTIERS MEDIA SA, 2021, 1664-8021

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10603 Genetics and heredity

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.772

RIV identification code

RIV/00216224:14110/21:00120172

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fgene.2021.692897

UT WoS

000717298400001

Keywords in English

male infertility; spermatogenesis; steroidogenesis; endocrine disrupting chemicals; bisphenol; spermatozoa; perfluoroalkyl substances

Abstract

V originále

Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men's fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

EF19_074/0012727, research and development project

Name: MSCAfellow3@MUNI

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

NV18-08-00412, research and development project

Name: Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

Investor: Ministry of Health of the CR

Citovat

JEŠETA, Michal, Jana NAVRÁTILOVÁ, Kateřina FRANZOVÁ, Sandra FIALKOVÁ, Bartozs KEMPISTY, Pavel VENTRUBA, Jana ŽÁKOVÁ and Igor CRHA. Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes. Frontiers in Genetics. Laussane: FRONTIERS MEDIA SA, 2021, vol. 12, September 2021, p. 1-13. ISSN 1664-8021. Available from: https://dx.doi.org/10.3389/fgene.2021.692897.

@article{1807758,
   author = {Ješeta, Michal and Navrátilová, Jana and Franzová, Kateřina and Fialková, Sandra and Kempisty, Bartozs and Ventruba, Pavel and Žáková, Jana and Crha, Igor},
   article_location = {Laussane},
   article_number = {September 2021},
   doi = {http://dx.doi.org/10.3389/fgene.2021.692897},
   keywords = {male infertility; spermatogenesis; steroidogenesis; endocrine disrupting chemicals; bisphenol; spermatozoa; perfluoroalkyl substances},
   language = {eng},
   issn = {1664-8021},
   journal = {Frontiers in Genetics},
   title = {Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes},
   url = {https://www.frontiersin.org/articles/10.3389/fgene.2021.692897/full},
   volume = {12},
   year = {2021}
}

TY  - JOUR
ID  - 1807758
AU  - Ješeta, Michal - Navrátilová, Jana - Franzová, Kateřina - Fialková, Sandra - Kempisty, Bartozs - Ventruba, Pavel - Žáková, Jana - Crha, Igor
PY  - 2021
TI  - Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes
JF  - Frontiers in Genetics
VL  - 12
IS  - September 2021
SP  - 1-13
EP  - 1-13
PB  - FRONTIERS MEDIA SA
SN  - 16648021
KW  - male infertility
KW  - spermatogenesis
KW  - steroidogenesis
KW  - endocrine disrupting chemicals
KW  - bisphenol
KW  - spermatozoa
KW  - perfluoroalkyl substances
UR  - https://www.frontiersin.org/articles/10.3389/fgene.2021.692897/full
N2  - Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men's fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.

ER -

JEŠETA, Michal, Jana NAVRÁTILOVÁ, Kateřina FRANZOVÁ, Sandra FIALKOVÁ, Bartozs KEMPISTY, Pavel VENTRUBA, Jana ŽÁKOVÁ and Igor CRHA. Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes. \textit{Frontiers in Genetics}. Laussane: FRONTIERS MEDIA SA, 2021, vol.~12, September 2021, p.~1-13. ISSN~1664-8021. Available from: https://dx.doi.org/10.3389/fgene.2021.692897.

Detailed Information on Publication Record