| JEŠETA, Michal, Jana NAVRÁTILOVÁ, Kateřina FRANZOVÁ, Sandra FIALKOVÁ, Bartozs KEMPISTY, Pavel VENTRUBA, Jana ŽÁKOVÁ and Igor CRHA. Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes. Frontiers in Genetics. Laussane: FRONTIERS MEDIA SA, 2021, vol. 12, September 2021, p. 1-13. ISSN 1664-8021. Available from: https://dx.doi.org/10.3389/fgene.2021.692897. |
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@article{1807758,
author = {Ješeta, Michal and Navrátilová, Jana and Franzová, Kateřina and Fialková, Sandra and Kempisty, Bartozs and Ventruba, Pavel and Žáková, Jana and Crha, Igor},
article_location = {Laussane},
article_number = {September 2021},
doi = {http://dx.doi.org/10.3389/fgene.2021.692897},
keywords = {male infertility; spermatogenesis; steroidogenesis; endocrine disrupting chemicals; bisphenol; spermatozoa; perfluoroalkyl substances},
language = {eng},
issn = {1664-8021},
journal = {Frontiers in Genetics},
title = {Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes},
url = {https://www.frontiersin.org/articles/10.3389/fgene.2021.692897/full},
volume = {12},
year = {2021}
}
TY - JOUR ID - 1807758 AU - Ješeta, Michal - Navrátilová, Jana - Franzová, Kateřina - Fialková, Sandra - Kempisty, Bartozs - Ventruba, Pavel - Žáková, Jana - Crha, Igor PY - 2021 TI - Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes JF - Frontiers in Genetics VL - 12 IS - September 2021 SP - 1-13 EP - 1-13 PB - FRONTIERS MEDIA SA SN - 16648021 KW - male infertility KW - spermatogenesis KW - steroidogenesis KW - endocrine disrupting chemicals KW - bisphenol KW - spermatozoa KW - perfluoroalkyl substances UR - https://www.frontiersin.org/articles/10.3389/fgene.2021.692897/full N2 - Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men's fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.
ER - JEŠETA, Michal, Jana NAVRÁTILOVÁ, Kateřina FRANZOVÁ, Sandra FIALKOVÁ, Bartozs KEMPISTY, Pavel VENTRUBA, Jana ŽÁKOVÁ and Igor CRHA. Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes. \textit{Frontiers in Genetics}. Laussane: FRONTIERS MEDIA SA, 2021, vol.~12, September 2021, p.~1-13. ISSN~1664-8021. Available from: https://dx.doi.org/10.3389/fgene.2021.692897.
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