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@article{1807762,
author = {Herman, Dalibor and Osmancik, Pavel and Neuzil, Petr and Hala, Pavel and Lekesova, Veronika and Benešová, Klára and Hozman, Marek and Jarkovský, Jiří and Nováčková, Martina and Widimsky, Petr and Reddy, V. Y.},
article_location = {HOBOKEN},
article_number = {10},
doi = {http://dx.doi.org/10.1111/jce.15206},
keywords = {atrial natriuretic peptide; biomarkers; brain natriuretic peptide; left atrial appendage; left atrial appendage closure},
language = {eng},
issn = {1045-3873},
journal = {JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY},
title = {The effect of left atrial appendage closure on heart failure biomarkers: A PRAGUE-17 trial subanalysis},
url = {https://onlinelibrary.wiley.com/doi/10.1111/jce.15206},
volume = {32},
year = {2021}
}
TY - JOUR
ID - 1807762
AU - Herman, Dalibor - Osmancik, Pavel - Neuzil, Petr - Hala, Pavel - Lekesova, Veronika - Benešová, Klára - Hozman, Marek - Jarkovský, Jiří - Nováčková, Martina - Widimsky, Petr - Reddy, V. Y.
PY - 2021
TI - The effect of left atrial appendage closure on heart failure biomarkers: A PRAGUE-17 trial subanalysis
JF - JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
VL - 32
IS - 10
SP - 2645-2654
EP - 2645-2654
PB - WILEY
SN - 10453873
KW - atrial natriuretic peptide
KW - biomarkers
KW - brain natriuretic peptide
KW - left atrial appendage
KW - left atrial appendage closure
UR - https://onlinelibrary.wiley.com/doi/10.1111/jce.15206
N2 - Introduction The randomized PRAGUE-17 trial demonstrated noninferiority of left atrial appendage closure (LAAC) to non-vitamin K anticoagulants (NOACs) for the prevention of major cardiovascular or cerebrovascular events. However, the left atrial appendage is an important source of natriuretic peptides and plays a role in left atrial reservoir function. Changes of heart failure (HF) biomarkers after LAAC compared to NOAC has not been studied. The aim of the study was to compare the changes in concentrations of HF biomarkers between LAAC and NOAC patients. Methods Of 402 patients randomized in the PRAGUE-17 trial, biomarkers were analyzed in 144 patients (73 in the NOAC and 71 in the LAAC group). Both groups had similar baseline characteristics. Serum concentration of NT-proBNP, NT-proANP, Galectin-3, and GDF-15 were measured at baseline (before the procedure in the LAAC group), at the 6-month (and at 24-month for NT-proBNP) follow-up timepoint. Results There were no significant differences in baseline, 6 month, and delta (delta = baseline - 6 month) concentrations of NT-proANP between the groups (NOAC: baseline 2.6 [0.5; 4.9], 6-month 3.1 [1.8; 4.8], p = .068; LAAC: baseline 3.3 [1.1; 4.6], 6-month 2.6 [0.9; 5.3], p = .51; p value for delta in concentrations between groups = 0.42). Similarly, there were no significant differences in baseline, 6, 24 months, and delta concentrations of NT-proBNP between the groups (NOAC: baseline 461.0 [113.5; 1342.0], 6 month 440.0 [120.5; 1291.5], 24 month 798 [274; 2236], p = .39; LAAC: baseline 421.0 [100.0; 1320.0], 6 month 601.0 [145.0; 1230.0], 24 month 855 [410; 1367], p = .28; p value for delta in concentrations between groups = 0.73 at 6 months, and 0.58 at 24 months). Finally, no significant differences were present in baseline, 6 month, and delta concentrations of Galectin-3 and GDF-15 between the two groups. Conclusion LAAC did not significantly influence the levels of HF biomarkers 6 months after the procedure.
ER -
HERMAN, Dalibor, Pavel OSMANCIK, Petr NEUZIL, Pavel HALA, Veronika LEKESOVA, Klára BENEŠOVÁ, Marek HOZMAN, Jiří JARKOVSKÝ, Martina NOVÁČKOVÁ, Petr WIDIMSKY and V. Y. REDDY. The effect of left atrial appendage closure on heart failure biomarkers: A PRAGUE-17 trial subanalysis. \textit{JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY}. HOBOKEN: WILEY, 2021, vol.~32, No~10, p.~2645-2654. ISSN~1045-3873. Available from: https://dx.doi.org/10.1111/jce.15206.
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