Plasma Levels of Long-Acting Injectable Antipsychotics in
Outpatient Care: A Retrospective Analysis

J 2021

Plasma Levels of Long-Acting Injectable Antipsychotics in Outpatient Care: A Retrospective Analysis

HYZA, M., P. SILHAN, E. CESKOVA, T. SKRONT, I. KACIROVA et. al.

Basic information

Original name

Plasma Levels of Long-Acting Injectable Antipsychotics in Outpatient Care: A Retrospective Analysis

Authors

HYZA, M., P. SILHAN, E. CESKOVA, T. SKRONT, I. KACIROVA, R. URINOVSKA and M. GRUNDMANN

Edition

Neuropsychiatric Disease and Treatment, New Zealand, Dove Medical Press, 2021, 1176-6328

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.154 in 2013

DOI

http://dx.doi.org/10.2147/NDT.S298050

UT WoS

000641063300001

Keywords in English

therapeutic drug monitoring; antipsychotics; psychotic disorders; schizophrenia

Abstract

V originále

Purpose: Antipsychotic efficacy in schizophrenia depends on its availability in the body. Although therapeutic outcomes remain still far from satisfactory, therapeutic drug monitoring not a common part of clinical practice during treatment with long-acting injectable antipsychotics (LAI AP). The real effectiveness of LAI AP is thus uncertain. Patients and Methods: We made a retrospective evaluation of plasma levels of LAI AP. Collection of blood samples was performed just before the drug application and one week later. Forty patients with a stabilized clinical condition and steady-state plasma levels were included. Results: In the observed cohort of patients, flupentixol decanoate (n = 23) was the most often used drug, followed by fluphenazine decanoate (n = 7), haloperidol decanoate (n = 5), paliperidone palmitate (n = 3), and risperidone microspheres (n = 2). Just 5 of 40 patients were treated with a monotherapy. In the period before the application, 60% of the patients did not reach the therapeutic reference range (TRR) and 20% of the patients had an undetectable plasma level. At the time of collection of the second blood samples performed after 7 days, 24% of the patients were under the TRR. Conclusion: We have found a surprisingly high incidence of plasma levels under the TRR patients treated with LAI AP. Notwithstanding individual variability in pharmacokinetics, seems that LAI AP may be underdosed in usual clinical practice.

Links

90128, large research infrastructures

Name: CZECRIN III

Citovat

HYZA, M., P. SILHAN, E. CESKOVA, T. SKRONT, I. KACIROVA, R. URINOVSKA and M. GRUNDMANN. Plasma Levels of Long-Acting Injectable Antipsychotics in Outpatient Care: A Retrospective Analysis. Neuropsychiatric Disease and Treatment. New Zealand: Dove Medical Press, 2021, vol. 17, p. 1069-1075. ISSN 1176-6328. Available from: https://dx.doi.org/10.2147/NDT.S298050.

@article{1807988,
   author = {Hyza, M. and Silhan, P. and Ceskova, E. and Skront, T. and Kacirova, I. and Urinovska, R. and Grundmann, M.},
   article_location = {New Zealand},
   doi = {http://dx.doi.org/10.2147/NDT.S298050},
   keywords = {therapeutic drug monitoring; antipsychotics; psychotic disorders; schizophrenia},
   language = {eng},
   issn = {1176-6328},
   journal = {Neuropsychiatric Disease and Treatment},
   title = {Plasma Levels of Long-Acting Injectable Antipsychotics in Outpatient Care: A Retrospective Analysis},
   url = {https://www.dovepress.com/plasma-levels-of-long-acting-injectable-antipsychotics-in-outpatient-c-peer-reviewed-fulltext-article-NDT},
   volume = {17},
   year = {2021}
}

TY  - JOUR
ID  - 1807988
AU  - Hyza, M. - Silhan, P. - Ceskova, E. - Skront, T. - Kacirova, I. - Urinovska, R. - Grundmann, M.
PY  - 2021
TI  - Plasma Levels of Long-Acting Injectable Antipsychotics in Outpatient Care: A Retrospective Analysis
JF  - Neuropsychiatric Disease and Treatment
VL  - 17
SP  - 1069-1075
EP  - 1069-1075
PB  - Dove Medical Press
SN  - 11766328
KW  - therapeutic drug monitoring
KW  - antipsychotics
KW  - psychotic disorders
KW  - schizophrenia
UR  - https://www.dovepress.com/plasma-levels-of-long-acting-injectable-antipsychotics-in-outpatient-c-peer-reviewed-fulltext-article-NDT
N2  - Purpose: Antipsychotic efficacy in schizophrenia depends on its availability in the body. Although therapeutic outcomes remain still far from satisfactory, therapeutic drug monitoring not a common part of clinical practice during treatment with long-acting injectable antipsychotics (LAI AP). The real effectiveness of LAI AP is thus uncertain. Patients and Methods: We made a retrospective evaluation of plasma levels of LAI AP. Collection of blood samples was performed just before the drug application and one week later. Forty patients with a stabilized clinical condition and steady-state plasma levels were included. Results: In the observed cohort of patients, flupentixol decanoate (n = 23) was the most often used drug, followed by fluphenazine decanoate (n = 7), haloperidol decanoate (n = 5), paliperidone palmitate (n = 3), and risperidone microspheres (n = 2). Just 5 of 40 patients were treated with a monotherapy. In the period before the application, 60% of the patients did not reach the therapeutic reference range (TRR) and 20% of the patients had an undetectable plasma level. At the time of collection of the second blood samples performed after 7 days, 24% of the patients were under the TRR. Conclusion: We have found a surprisingly high incidence of plasma levels under the TRR patients treated with LAI AP. Notwithstanding individual variability in pharmacokinetics, seems that LAI AP may be underdosed in usual clinical practice.
ER  -

HYZA, M., P. SILHAN, E. CESKOVA, T. SKRONT, I. KACIROVA, R. URINOVSKA and M. GRUNDMANN. Plasma Levels of Long-Acting Injectable Antipsychotics in Outpatient Care: A Retrospective Analysis. \textit{Neuropsychiatric Disease and Treatment}. New Zealand: Dove Medical Press, 2021, vol.~17, p.~1069-1075. ISSN~1176-6328. Available from: https://dx.doi.org/10.2147/NDT.S298050.

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