USTOHAL, Libor, Michaela MAYEROVÁ, Kateřina HORSKÁ, Marie OBDRŽÁLKOVÁ, Hana CRHOVÁ, Hana PŘIKRYLOVÁ KUČEROVÁ, Eva ČEŠKOVÁ and Tomáš KAŠPÁREK. Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study. International Journal of Psychiatry in Clinical Practice. ABINGDON: TAYLOR & FRANCIS LTD, 2022, vol. 26, No 2, p. 213-216. ISSN 1365-1501. Available from: https://dx.doi.org/10.1080/13651501.2021.1962357.
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Basic information
Original name Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study
Authors USTOHAL, Libor (203 Czech Republic, belonging to the institution), Michaela MAYEROVÁ (203 Czech Republic, belonging to the institution), Kateřina HORSKÁ (203 Czech Republic, guarantor, belonging to the institution), Marie OBDRŽÁLKOVÁ (203 Czech Republic, belonging to the institution), Hana CRHOVÁ (203 Czech Republic, belonging to the institution), Hana PŘIKRYLOVÁ KUČEROVÁ (203 Czech Republic, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution).
Edition International Journal of Psychiatry in Clinical Practice, ABINGDON, TAYLOR & FRANCIS LTD, 2022, 1365-1501.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.000
RIV identification code RIV/00216224:14160/22:00128993
Organization unit Faculty of Pharmacy
Doi http://dx.doi.org/10.1080/13651501.2021.1962357
UT WoS 000683657200001
Keywords in English First-episode psychosis; mean arterial pressure; monocyte-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio; pulse pressure; rate pressure product
Tags 14110222, podil, rivok, ÚFTo
Tags International impact, Reviewed
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 25/4/2023 14:50.
Abstract
Objective Patients with schizophrenia are at higher risk of cardiovascular (CVS) related mortality. Close attention is being paid to the clinical utility of readily available CVS markers. Methods A pilot one-year longitudinal study in inpatients with first-episode psychosis (FEP) was carried out to determine markers of inflammation and endothelial dysfunction (monocyte- and neutrophil-to-lymphocyte ratios) and basal blood pressure, pulse, and derived hemodynamic parameters (PP: pulse pressure; RPP: rate pressure product; and MAP: mean arterial pressure). Results After one year, PP and RPP increased, as did systolic blood pressure and heart rate. Systolic blood pressure, PP, total white blood cells, and neutrophils correlated with weight gain. After one year, correlations between monocyte-to-lymphocyte ratio and RPP and MAP were observed. Conclusion Our study indicates worsening CVS health over the first year of treatment and emphasises the importance of early monitoring of CVS status using easily accessible parameters to prevent CVS-related mortality.
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