J 2022

Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study

USTOHAL, Libor, Michaela MAYEROVÁ, Kateřina HORSKÁ, Marie OBDRŽÁLKOVÁ, Hana CRHOVÁ et. al.

Basic information

Original name

Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study

Authors

USTOHAL, Libor (203 Czech Republic, belonging to the institution), Michaela MAYEROVÁ (203 Czech Republic, belonging to the institution), Kateřina HORSKÁ (203 Czech Republic, guarantor, belonging to the institution), Marie OBDRŽÁLKOVÁ (203 Czech Republic, belonging to the institution), Hana CRHOVÁ (203 Czech Republic, belonging to the institution), Hana PŘIKRYLOVÁ KUČEROVÁ (203 Czech Republic, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution)

Edition

International Journal of Psychiatry in Clinical Practice, ABINGDON, TAYLOR & FRANCIS LTD, 2022, 1365-1501

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.000

RIV identification code

RIV/00216224:14160/22:00128993

Organization unit

Faculty of Pharmacy

DOI

UT WoS

000683657200001

Keywords in English

First-episode psychosis; mean arterial pressure; monocyte-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio; pulse pressure; rate pressure product

Tags

Tags

International impact, Reviewed
Změněno: 25/4/2023 14:50, Mgr. Michal Petr

Abstract

V originále

Objective Patients with schizophrenia are at higher risk of cardiovascular (CVS) related mortality. Close attention is being paid to the clinical utility of readily available CVS markers. Methods A pilot one-year longitudinal study in inpatients with first-episode psychosis (FEP) was carried out to determine markers of inflammation and endothelial dysfunction (monocyte- and neutrophil-to-lymphocyte ratios) and basal blood pressure, pulse, and derived hemodynamic parameters (PP: pulse pressure; RPP: rate pressure product; and MAP: mean arterial pressure). Results After one year, PP and RPP increased, as did systolic blood pressure and heart rate. Systolic blood pressure, PP, total white blood cells, and neutrophils correlated with weight gain. After one year, correlations between monocyte-to-lymphocyte ratio and RPP and MAP were observed. Conclusion Our study indicates worsening CVS health over the first year of treatment and emphasises the importance of early monitoring of CVS status using easily accessible parameters to prevent CVS-related mortality.