Utilization of Pharmaceutical Technology Methods for the
Development of Innovative Porous Metasilicate Pellets with a
Very High Specific Surface Area for Chemical Warfare Agents
Detection

J 2021

Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection

ZEMAN, Jiří, Sylvie PAVLOKOVÁ, David VETCHÝ, Adam STAŇO, Zdeněk MORAVEC et. al.

Basic information

Original name

Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection

Authors

ZEMAN, Jiří (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, guarantor, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution), Adam STAŇO (703 Slovakia, belonging to the institution), Zdeněk MORAVEC (203 Czech Republic, belonging to the institution), Lukáš MATĚJOVSKÝ (203 Czech Republic) and Vladimír PITSCHMANN (203 Czech Republic)

Edition

Pharmaceutics, BASEL, MDPI, 2021, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.525

RIV identification code

RIV/00216224:14160/21:00120064

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/pharmaceutics13111860

UT WoS

000725292600001

Keywords in English

metasilicate; volatile substance; porous pellets; BET method; detection tube; extrusion; spheronization; chemical warfare agent; phosgene

Abstract

V originále

Pharmaceutical technology offers various dosage forms that can be applied interdisciplinary. One of them are spherical pellets which could be utilized as a carrier in emerging second-generation detection tubes. This detection system requires carriers with high specific surface area (SSA), which should allow better adsorption of toxic substances and detection reagents. In this study, a magnesium aluminometasilicate with high SSA was utilized along with various concentrations of volatile substances (menthol, camphor and ammonium bicarbonate) to increase further the carrier SSA after their sublimation. The samples were evaluated in terms of physicochemical parameters, their morphology was assessed by scanning electron microscopy, and the Brunauer-Emmett-Teller (BET) method was utilized to measure SSA. The samples were then impregnated with a detection reagent o-phenylenediamine-pyronine and tested with diphosgene. Only samples prepared using menthol or camphor were found to show red fluorescence under the UV light in addition to the eye-visible red-violet color. This allowed the detection of diphosgene/phosgene at a concentration of only 0.1 mg/m(3) in the air for samples M20.0 and C20.0 with their SSA higher than 115 m(2)/g, thus exceeding the sensitivity of the first-generation DT-12 detection tube.

Links

VI20192022172, research and development project

Name: Detekční trubičky druhé generace pro kontinuální a opakované monitorování nervově paralytických a jiných toxických látek

Investor: Ministry of the Interior of the CR

Citovat

ZEMAN, Jiří, Sylvie PAVLOKOVÁ, David VETCHÝ, Adam STAŇO, Zdeněk MORAVEC, Lukáš MATĚJOVSKÝ and Vladimír PITSCHMANN. Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection. Pharmaceutics. BASEL: MDPI, 2021, vol. 13, No 11, p. 1-15. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics13111860.

@article{1808508,
   author = {Zeman, Jiří and Pavloková, Sylvie and Vetchý, David and Staňo, Adam and Moravec, Zdeněk and Matějovský, Lukáš and Pitschmann, Vladimír},
   article_location = {BASEL},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/pharmaceutics13111860},
   keywords = {metasilicate; volatile substance; porous pellets; BET method; detection tube; extrusion; spheronization; chemical warfare agent; phosgene},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection},
   url = {https://www.mdpi.com/1999-4923/13/11/1860/htm},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1808508
AU  - Zeman, Jiří - Pavloková, Sylvie - Vetchý, David - Staňo, Adam - Moravec, Zdeněk - Matějovský, Lukáš - Pitschmann, Vladimír
PY  - 2021
TI  - Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection
JF  - Pharmaceutics
VL  - 13
IS  - 11
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 19994923
KW  - metasilicate
KW  - volatile substance
KW  - porous pellets
KW  - BET method
KW  - detection tube
KW  - extrusion
KW  - spheronization
KW  - chemical warfare agent
KW  - phosgene
UR  - https://www.mdpi.com/1999-4923/13/11/1860/htm
N2  - Pharmaceutical technology offers various dosage forms that can be applied interdisciplinary. One of them are spherical pellets which could be utilized as a carrier in emerging second-generation detection tubes. This detection system requires carriers with high specific surface area (SSA), which should allow better adsorption of toxic substances and detection reagents. In this study, a magnesium aluminometasilicate with high SSA was utilized along with various concentrations of volatile substances (menthol, camphor and ammonium bicarbonate) to increase further the carrier SSA after their sublimation. The samples were evaluated in terms of physicochemical parameters, their morphology was assessed by scanning electron microscopy, and the Brunauer-Emmett-Teller (BET) method was utilized to measure SSA. The samples were then impregnated with a detection reagent o-phenylenediamine-pyronine and tested with diphosgene. Only samples prepared using menthol or camphor were found to show red fluorescence under the UV light in addition to the eye-visible red-violet color. This allowed the detection of diphosgene/phosgene at a concentration of only 0.1 mg/m(3) in the air for samples M20.0 and C20.0 with their SSA higher than 115 m(2)/g, thus exceeding the sensitivity of the first-generation DT-12 detection tube.
ER  -

ZEMAN, Jiří, Sylvie PAVLOKOVÁ, David VETCHÝ, Adam STAŇO, Zdeněk MORAVEC, Lukáš MATĚJOVSKÝ and Vladimír PITSCHMANN. Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection. \textit{Pharmaceutics}. BASEL: MDPI, 2021, vol.~13, No~11, p.~1-15. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics13111860.

Detailed Information on Publication Record