Podrobný výpis o publikaci

ESCOLANO-LOZANO, F, E GRIES, T SCHLERETH, V DIMOVA, BAKA, Eva VLČKOVÁ, S KONIG a F BIRKLEIN. Local and Systemic Expression Pattern of MMP-2 and MMP-9 in Complex Regional Pain Syndrome. JOURNAL OF PAIN. EDINBURGH: CHURCHILL LIVINGSTONE, 2021, roč. 22, č. 10, s. 1294-1302. ISSN 1526-5900. Dostupné z: https://dx.doi.org/10.1016/j.jpain.2021.04.002.

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TY  - JOUR
ID  - 1808657
AU  - Escolano-Lozano, F - Gries, E - Schlereth, T - Dimova, V - Baka,
AU  - Vlčková, Eva - Konig, S - Birklein, F
PY  - 2021
TI  - Local and Systemic Expression Pattern of MMP-2 and MMP-9 in Complex Regional Pain Syndrome
JF  - JOURNAL OF PAIN
VL  - 22
IS  - 10
SP  - 1294-1302
EP  - 1294-1302
PB  - CHURCHILL LIVINGSTONE
SN  - 15265900
N1  - Bez afiliace k MU.
KW  - Complex regional pain syndrome
KW  - matrix metalloproteinases
KW  - pain
KW  - inflammation
KW  - Complex regional pain syndrome severity score
N2  - Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy subjects. All samples were analyzed with ELISA. Concentrations were then compared to clinical data as well as to quantitative sensory testing data.MMP-2 was increased in both ipsi- and contralateral skin biopsies of CRPS patients compared to healthy subjects. While low ipsilateral MMP-2 was associated with trophic changes, contralateral MMP-2 inversely correlated with the CRPS severity. MMP-9 was also locally increased in ipsilateral CRPS skin, and higher ipsi- and contralateral MMP-9 levels correlated with CRPS severity. We conclude that MMP-2 and MMP-9 are differently expressed depending on the clinical phenotype in CRPS. Perspective: This article describes an upregulation of MMPs in CRPS and pain controls and shows different expression of MMP-2 and -9 depending on clinical phenotype in CRPS. These results provide evidence that MMP-2 and -9 play a key role in CRPS pathophysiology. (C) 2021 by United States Association for the Study of Pain, Inc.
ER  -

Základní údaje
Originální název	Local and Systemic Expression Pattern of MMP-2 and MMP-9 in Complex Regional Pain Syndrome
Autoři	ESCOLANO-LOZANO, F, E GRIES, T SCHLERETH, V DIMOVA, BAKA, Eva VLČKOVÁ, S KONIG a F BIRKLEIN.
Vydání	JOURNAL OF PAIN, EDINBURGH, CHURCHILL LIVINGSTONE, 2021, 1526-5900.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Utajení	není předmětem státního či obchodního tajemství
Impakt faktor	Impact factor: 5.383
Organizační jednotka	Lékařská fakulta
Doi	http://dx.doi.org/10.1016/j.jpain.2021.04.002
UT WoS	000705022800013
Klíčová slova anglicky	Complex regional pain syndrome; matrix metalloproteinases; pain; inflammation; Complex regional pain syndrome severity score
Změnil	Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 10. 12. 2021 13:28.

Anotace
Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy subjects. All samples were analyzed with ELISA. Concentrations were then compared to clinical data as well as to quantitative sensory testing data.MMP-2 was increased in both ipsi- and contralateral skin biopsies of CRPS patients compared to healthy subjects. While low ipsilateral MMP-2 was associated with trophic changes, contralateral MMP-2 inversely correlated with the CRPS severity. MMP-9 was also locally increased in ipsilateral CRPS skin, and higher ipsi- and contralateral MMP-9 levels correlated with CRPS severity. We conclude that MMP-2 and MMP-9 are differently expressed depending on the clinical phenotype in CRPS. Perspective: This article describes an upregulation of MMPs in CRPS and pain controls and shows different expression of MMP-2 and -9 depending on clinical phenotype in CRPS. These results provide evidence that MMP-2 and -9 play a key role in CRPS pathophysiology. (C) 2021 by United States Association for the Study of Pain, Inc.

Anotace

Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy subjects. All samples were analyzed with ELISA. Concentrations were then compared to clinical data as well as to quantitative sensory testing data.MMP-2 was increased in both ipsi- and contralateral skin biopsies of CRPS patients compared to healthy subjects. While low ipsilateral MMP-2 was associated with trophic changes, contralateral MMP-2 inversely correlated with the CRPS severity. MMP-9 was also locally increased in ipsilateral CRPS skin, and higher ipsi- and contralateral MMP-9 levels correlated with CRPS severity. We conclude that MMP-2 and MMP-9 are differently expressed depending on the clinical phenotype in CRPS. Perspective: This article describes an upregulation of MMPs in CRPS and pain controls and shows different expression of MMP-2 and -9 depending on clinical phenotype in CRPS. These results provide evidence that MMP-2 and -9 play a key role in CRPS pathophysiology. (C) 2021 by United States Association for the Study of Pain, Inc.