ŠTOURAČ, Pavel, Jana BEDNÁŘOVÁ, Pavel ZICHACEK, Zdena CERMAKOVA, Zbysek PAVELEK and Martin VALIS. Autoimmune and limbic encephalitis: case series with some atypical variables in clinical practice. NEUROLOGICAL SCIENCES. New York: Springer, 2022, vol. 43, No 1, p. 687-690. ISSN 1590-1874. Available from: https://dx.doi.org/10.1007/s10072-021-05563-x.
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Basic information
Original name Autoimmune and limbic encephalitis: case series with some atypical variables in clinical practice
Authors ŠTOURAČ, Pavel (203 Czech Republic, guarantor, belonging to the institution), Jana BEDNÁŘOVÁ (203 Czech Republic, belonging to the institution), Pavel ZICHACEK (203 Czech Republic), Zdena CERMAKOVA (203 Czech Republic), Zbysek PAVELEK (203 Czech Republic) and Martin VALIS (203 Czech Republic).
Edition NEUROLOGICAL SCIENCES, New York, Springer, 2022, 1590-1874.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.300
RIV identification code RIV/00216224:14110/22:00125087
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s10072-021-05563-x
UT WoS 000687902800001
Keywords in English Autoimmune and limbic encephalitis; Anti-N-methyl-D-aspartate receptor antibodies
Tags 14110221
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 1/2/2022 10:25.
Abstract
Autoimmune and limbic encephalitides are still rare diseases characterized by rapid diagnostics and treatment development in recent years. The incidence of anti-N-methyl-D- aspartate receptor [NMDAR] encephalitis is about 1.5 per million person per year, and the incidence of paraneoplastic neurological syndromes [PNS] including limbic encephalitis [LE] is about 1.22 per 100 000 person per year (Vogrig et al. J Neurol 267:26-35, 1; Dalmau et al. Ann Neurol 61:25-36, 2). The diagnostic criteria of anti-NMDAR encephalitis are already well established (Zuliani et al. Neurol Sci 40:2017-2030, 10). We provide immunological and clinical characteristics of anti-NMDAR encephalitis case series emphasizing unusual association with colon tumour in one case and complete recovery in two cases. Then we report two cases of onconeural and cell surface antibody negative limbic encephalitis [LE] associated with tumours, seizures, cognitive and behavioural changes resulting in severe cerebellar syndrome and fatal outcome. The clinical characteristics and results of selected paraclinical examinations as electroencephalography [EEG], magnetic resonance imaging [MRI] and cerebrospinal fluid [CSF] analysis are reviewed.
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