| MANOUSEK, Jan, Petr KALA, Petr LOKAJ, Tomáš ONDRÚŠ, Kateřina HELÁNOVÁ, Marie MIKLÍKOVÁ, Vojtěch BRÁZDIL, Marie TOMANDLOVÁ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ and Jiří HLÁSENSKÝ. Oxidative Stress in Takotsubo Syndrome-Is It Essential for an Acute Attack? Indirect Evidences Support Multisite Impact Including the Calcium Overload-Energy Failure Hypothesis. FRONTIERS IN CARDIOVASCULAR MEDICINE. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol. 8, October 2021, p. 1-22. ISSN 2297-055X. Available from: https://dx.doi.org/10.3389/fcvm.2021.732708. |
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@article{1809312,
author = {Manousek, Jan and Kala, Petr and Lokaj, Petr and Ondrúš, Tomáš and Helánová, Kateřina and Miklíková, Marie and Brázdil, Vojtěch and Tomandlová, Marie and Pařenica, Jiří and Pávková Goldbergová, Monika and Hlásenský, Jiří},
article_location = {LAUSANNE},
article_number = {October 2021},
doi = {http://dx.doi.org/10.3389/fcvm.2021.732708},
keywords = {Takotsubo syndrome; oxidative stress; catecholamines; cytochrome P450; sarco(endo)plasmic reticulum; mitochondria complex; calcium overload; energy failure; antioxidants},
language = {eng},
issn = {2297-055X},
journal = {FRONTIERS IN CARDIOVASCULAR MEDICINE},
title = {Oxidative Stress in Takotsubo Syndrome-Is It Essential for an Acute Attack? Indirect Evidences Support Multisite Impact Including the Calcium Overload-Energy Failure Hypothesis},
url = {https://www.frontiersin.org/articles/10.3389/fcvm.2021.732708/full},
volume = {8},
year = {2021}
}
TY - JOUR ID - 1809312 AU - Manousek, Jan - Kala, Petr - Lokaj, Petr - Ondrúš, Tomáš - Helánová, Kateřina - Miklíková, Marie - Brázdil, Vojtěch - Tomandlová, Marie - Pařenica, Jiří - Pávková Goldbergová, Monika - Hlásenský, Jiří PY - 2021 TI - Oxidative Stress in Takotsubo Syndrome-Is It Essential for an Acute Attack? Indirect Evidences Support Multisite Impact Including the Calcium Overload-Energy Failure Hypothesis JF - FRONTIERS IN CARDIOVASCULAR MEDICINE VL - 8 IS - October 2021 SP - 1-22 EP - 1-22 PB - FRONTIERS MEDIA SA SN - 2297055X KW - Takotsubo syndrome KW - oxidative stress KW - catecholamines KW - cytochrome P450 KW - sarco(endo)plasmic reticulum KW - mitochondria complex KW - calcium overload KW - energy failure KW - antioxidants UR - https://www.frontiersin.org/articles/10.3389/fcvm.2021.732708/full N2 - Indirect evidences in reviews and case reports on Takotsubo syndrome (TTS) support the fact that the existence of oxidative stress (OS) might be its common feature in the pre-acute stage. The sources of OS are exogenous (environmental factors including pharmacological and toxic influences) and endogenous, the combination of both may be present, and they are being discussed in detail. OS is associated with several pathological conditions representing TTS comorbidities and triggers. The dominant source of OS electrones are mitochondria. Our analysis of drug therapy related to acute TTS shows many interactions, e.g., cytostatics and glucocorticoids with mitochondrial cytochrome P450 and other enzymes important for OS. One of the most frequently discussed mechanisms in TTS is the effect of catecholamines on myocardium. Yet, their metabolic influence is neglected. OS is associated with the oxidation of catecholamines leading to the synthesis of their oxidized forms - aminochromes. Under pathological conditions, this pathway may dominate. There are evidences of interference between OS, catecholamine/aminochrome effects, their metabolism and antioxidant protection. The OS offensive may cause fast depletion of antioxidant protection including the homocystein-methionine system, whose activity decreases with age. The alteration of effector subcellular structures (mitochondria, sarco/endoplasmic reticulum) and subsequent changes in cellular energetics and calcium turnover may also occur and lead to the disruption of cellular function, including neurons and cardiomyocytes. On the organ level (nervous system and heart), neurocardiogenic stunning may occur. The effects of OS correspond to the effect of high doses of catecholamines in the experiment. Intensive OS might represent "conditio sine qua non" for this acute clinical condition. TTS might be significantly more complex pathology than currently perceived so far.
ER - MANOUSEK, Jan, Petr KALA, Petr LOKAJ, Tomáš ONDRÚŠ, Kateřina HELÁNOVÁ, Marie MIKLÍKOVÁ, Vojtěch BRÁZDIL, Marie TOMANDLOVÁ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ and Jiří HLÁSENSKÝ. Oxidative Stress in Takotsubo Syndrome-Is It Essential for an Acute Attack? Indirect Evidences Support Multisite Impact Including the Calcium Overload-Energy Failure Hypothesis. \textit{FRONTIERS IN CARDIOVASCULAR MEDICINE}. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol.~8, October 2021, p.~1-22. ISSN~2297-055X. Available from: https://dx.doi.org/10.3389/fcvm.2021.732708.
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