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@article{1809397,
author = {Hanicinec, Vojtech and Brynychova, Veronika and Rosendorf, Jachym and Palek, Richard and Liska, Vaclav and Oliverius, Martin and Kala, Zdeněk and MohelnikovaandDuchonova, Beatrice and Krus, Ivona and Soucek, Pavel},
article_location = {Athens},
article_number = {2},
doi = {http://dx.doi.org/10.3892/ol.2021.12859},
keywords = {gene expression; cytokinesis; colon; rectum; pancreas; cancer; prognosis},
language = {eng},
issn = {1792-1074},
journal = {Oncology Letters},
title = {Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer},
url = {https://www.spandidos-publications.com/10.3892/ol.2021.12859},
volume = {22},
year = {2021}
}
TY - JOUR
ID - 1809397
AU - Hanicinec, Vojtech - Brynychova, Veronika - Rosendorf, Jachym - Palek, Richard - Liska, Vaclav - Oliverius, Martin - Kala, Zdeněk - Mohelnikova-Duchonova, Beatrice - Krus, Ivona - Soucek, Pavel
PY - 2021
TI - Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
JF - Oncology Letters
VL - 22
IS - 2
SP - 1-12
EP - 1-12
PB - Spandidos Publications
SN - 17921074
KW - gene expression
KW - cytokinesis
KW - colon
KW - rectum
KW - pancreas
KW - cancer
KW - prognosis
UR - https://www.spandidos-publications.com/10.3892/ol.2021.12859
N2 - Colorectal cancer is one of the most common cancers and pancreatic cancer is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to improve the treatment of colorectal and pancreatic cancer. Protein regulating cytokinesis 1 (PRC1), kinesin family member 14 (KIF14) and citron Rho-interacting serine/threonine kinase (CIT) serve important roles in cytokinesis, are strongly associated with cancer progression and have prognostic potential. The present study aimed to investigate the prognostic relevance of the PRC1, KIF14 and CIT genes in colorectal and pancreatic cancer. PRC1, KIF14 and CIT transcript expression was assessed by reverse transcription-quantitative PCR in tumors and paired distant unaffected mucosa from 67 patients with colorectal cancer and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic cancer. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics, namely patients' age and sex, disease stage, localization and grade, was determined. Finally, the associations of transcript levels in tumors with disease-free interval and overall survival time were evaluated. PRC1, KIF14 and CIT transcripts were upregulated in tumors compared with control tissues. PRC1, KIF14 and CIT levels strongly correlated to each other in both colorectal and pancreatic tumor and control tissues after correction for multiple testing. However, no significant associations were found among the transcript levels of PRC1, KIF14 and CIT and disease-free interval or overall survival time. In summary, the present study demonstrated mutual correlation of PRC1, KIF14 and CIT cytokinesis regulators with no clear prognostic value in pancreatic and colorectal cancers. Hence, according to the results of the present study, transcript levels of these genes cannot be clinically exploited as prognostic biomarkers in colorectal or pancreatic cancer patients.
ER -
HANICINEC, Vojtech, Veronika BRYNYCHOVA, Jachym ROSENDORF, Richard PALEK, Vaclav LISKA, Martin OLIVERIUS, Zdeněk KALA, Beatrice MOHELNIKOVA-DUCHONOVA, Ivona KRUS and Pavel SOUCEK. Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer. \textit{Oncology Letters}. Athens: Spandidos Publications, 2021, vol.~22, No~2, p.~1-12. ISSN~1792-1074. Available from: https://dx.doi.org/10.3892/ol.2021.12859.
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