J 2021

Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer

HANICINEC, Vojtech, Veronika BRYNYCHOVA, Jachym ROSENDORF, Richard PALEK, Vaclav LISKA et. al.

Basic information

Original name

Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer

Authors

HANICINEC, Vojtech (203 Czech Republic), Veronika BRYNYCHOVA (203 Czech Republic), Jachym ROSENDORF (203 Czech Republic), Richard PALEK (203 Czech Republic), Vaclav LISKA (203 Czech Republic), Martin OLIVERIUS (203 Czech Republic), Zdeněk KALA (203 Czech Republic, belonging to the institution), Beatrice MOHELNIKOVA-DUCHONOVA (203 Czech Republic), Ivona KRUS (203 Czech Republic) and Pavel SOUCEK (203 Czech Republic, guarantor)

Edition

Oncology Letters, Athens, Spandidos Publications, 2021, 1792-1074

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.111

RIV identification code

RIV/00216224:14110/21:00123229

Organization unit

Faculty of Medicine

DOI

UT WoS

000667256200001

Keywords in English

gene expression; cytokinesis; colon; rectum; pancreas; cancer; prognosis

Tags

Tags

International impact, Reviewed
Změněno: 13/12/2021 10:54, Mgr. Tereza Miškechová

Abstract

V originále

Colorectal cancer is one of the most common cancers and pancreatic cancer is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to improve the treatment of colorectal and pancreatic cancer. Protein regulating cytokinesis 1 (PRC1), kinesin family member 14 (KIF14) and citron Rho-interacting serine/threonine kinase (CIT) serve important roles in cytokinesis, are strongly associated with cancer progression and have prognostic potential. The present study aimed to investigate the prognostic relevance of the PRC1, KIF14 and CIT genes in colorectal and pancreatic cancer. PRC1, KIF14 and CIT transcript expression was assessed by reverse transcription-quantitative PCR in tumors and paired distant unaffected mucosa from 67 patients with colorectal cancer and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic cancer. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics, namely patients' age and sex, disease stage, localization and grade, was determined. Finally, the associations of transcript levels in tumors with disease-free interval and overall survival time were evaluated. PRC1, KIF14 and CIT transcripts were upregulated in tumors compared with control tissues. PRC1, KIF14 and CIT levels strongly correlated to each other in both colorectal and pancreatic tumor and control tissues after correction for multiple testing. However, no significant associations were found among the transcript levels of PRC1, KIF14 and CIT and disease-free interval or overall survival time. In summary, the present study demonstrated mutual correlation of PRC1, KIF14 and CIT cytokinesis regulators with no clear prognostic value in pancreatic and colorectal cancers. Hence, according to the results of the present study, transcript levels of these genes cannot be clinically exploited as prognostic biomarkers in colorectal or pancreatic cancer patients.