J 2021

Health-related quality of life in women with autoimmune thyroid disease during pregnancy and postpartum: systematic review including 321,850 pregnancies

TUZIL, Jan, Jana BARTAKOVA, Torquil WATT and Tomáš DOLEŽAL

Basic information

Original name

Health-related quality of life in women with autoimmune thyroid disease during pregnancy and postpartum: systematic review including 321,850 pregnancies

Authors

TUZIL, Jan (203 Czech Republic, guarantor), Jana BARTAKOVA (203 Czech Republic), Torquil WATT (208 Denmark) and Tomáš DOLEŽAL (203 Czech Republic, belonging to the institution)

Edition

EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH, ABINGDON, TAYLOR & FRANCIS LTD, 2021, 1473-7167

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.039

RIV identification code

RIV/00216224:14110/21:00123230

Organization unit

Faculty of Medicine

DOI

UT WoS

000686823900001

Keywords in English

Thyroid disease; pregnancy; postpartum; quality of life; depression; anxiety; utility; thyroid autoimmunity; thyroid disorder

Tags

Tags

International impact, Reviewed
Změněno: 13/12/2021 11:07, Mgr. Tereza Miškechová

Abstract

V originále

Background Utilities of the general population or expert estimates have been used for all published cost-effectiveness analyses of screening for thyroid disorders in pregnancy. Methods A systematic review CRD42019120897 of studies with patient-reported outcomes (PRO) and laboratory evidence of thyroid function/autoimmunity was conducted using PubMed, Cochrane Central, EconLit, SocIndex, DARE, NHS EEDS, Annual Reviews, and CINAHL. Quality was assessed using Joanna Briggs Institute appraisal tool. Results Of 664 abstracts screened, we analyzed 97 full texts. All studies describing the impact of thyroid disease on the generic QoL excluded pregnant and postpartum women. 21 reports of acceptable quality (321,850 pregnancies) determined depression and anxiety with validated tools and/or reported subjective symptoms. During pregnancy, contradictory conclusions were published on the impact of thyroid disease on PRO. Postpartum, antithyroid antibodies coincide with alexithymia and depression, postpartum thyroiditis negatively impacts mood. No conclusion could be drawn on the impact of thyroid hormonal levels. Conclusions The generic QoL in autoimmune thyroid disease during pregnancy has never been described, which represents an obstacle for the construction of economic models. We found contradictory information on the impact of thyroid disease on depression, anxiety, and specific symptoms.