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@proceedings{1809479,
author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Kollár, Peter and Bobáľ, Pavel},
booktitle = {Student scientific conference MUNI PHARM 2021},
keywords = {HDAC inhibitors; Hydroxamic acid; Antiproliferative activity},
language = {eng},
isbn = {978-80-210-9870-1},
title = {Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide},
url = {https://www.pharm.muni.cz/veda-a-vyzkum/svk/2021/sbornik-abstrakt},
year = {2021}
}
TY - CONF
ID - 1809479
AU - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Kollár, Peter - Bobáľ, Pavel
PY - 2021
TI - Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide
SN - 9788021098701
KW - HDAC inhibitors
KW - Hydroxamic acid
KW - Antiproliferative activity
UR - https://www.pharm.muni.cz/veda-a-vyzkum/svk/2021/sbornik-abstrakt
N2 - Histone acetylation is a process controlled by histone deacetylases (HDAC) and histone acetyltransferases (HAT), and it plays an essential role in the regulation of gene expression. HDACs are a family of enzymes that modulate the acetylation status of histones and non-histone proteins. Inhibitors of HDAC (HDACi), which form a complex with Zn2+ ion in the enzyme active site, are novel antiproliferative agents that induce tumor cell death, differentiation, and/or cell cycle arrest.
ER -
ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR a Pavel BOBÁĽ. Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide. In \textit{Student scientific conference MUNI PHARM 2021}. 2021. ISBN~978-80-210-9870-1.
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