Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR and Pavel BOBÁĽ. Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide. In Student scientific conference MUNI PHARM 2021. 2021. ISBN 978-80-210-9870-1.

Basic information

• Original name: Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide
• Authors: ONUŠČÁKOVÁ, Magdaléna (703 Slovakia, guarantor, belonging to the institution), Hana PÍŽOVÁ (203 Czech Republic, belonging to the institution), Tereza KAUEROVÁ (203 Czech Republic, belonging to the institution), Peter KOLLÁR (203 Czech Republic, belonging to the institution) and Pavel BOBÁĽ (703 Slovakia, belonging to the institution).
• Edition: Student scientific conference MUNI PHARM 2021, 2021.

Other information

• Original language: English
• Type of outcome: Presentations at conferences
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: Sborník abstrakt
• RIV identification code: RIV/00216224:14160/21:00123234
• Organization unit: Faculty of Pharmacy
• ISBN: 978-80-210-9870-1
• Keywords in English: HDAC inhibitors; Hydroxamic acid; Antiproliferative activity
• Tags: ÚChL, ÚFTo

Abstract

Histone acetylation is a process controlled by histone deacetylases (HDAC) and histone acetyltransferases (HAT), and it plays an essential role in the regulation of gene expression. HDACs are a family of enzymes that modulate the acetylation status of histones and non-histone proteins. Inhibitors of HDAC (HDACi), which form a complex with Zn2+ ion in the enzyme active site, are novel antiproliferative agents that induce tumor cell death, differentiation, and/or cell cycle arrest.

Abstract (in Czech)

Acetylace histonů je proces řízený histondeacetylázami (HDAC) a histonacetyltransferázami (HAT) a hraje zásadní roli v regulaci genové exprese. HDAC jsou rodinou metaloenzymů, které modulují stav acetylace histonů a nehistonových proteinů. Inhibitory HDAC (HDACi), které tvoří komplex s iontem Zn2+ v aktivním místě enzymu, jsou nové antiproliferativní látky, které vyvolávají smrt nádorových buněk, diferenciaci a/nebo zástavu buněčného cyklu.

Links

• MUNI/A/1598/2020, interní kód MU: Name: Analýza antiproliferačních, proapoptotických a cytodiferenciačních účinků nově syntetizovaných hydroxamových kyselin

Investor: Masaryk University

• MUNI/A/1682/2020, interní kód MU: Name: Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou

Investor: Masaryk University