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@proceedings{1809543,
author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Kollár, Peter and Bobáľ, Pavel},
booktitle = {49th Conference Synthesis and Analysis of Drugs},
keywords = {HDAC inhibitors Antiproliferative activity},
language = {eng},
title = {Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates},
url = {https://www.faf.cuni.cz/getattachment/Special/SAL2021/Program/SAD2021_Book-of-Abstracts_v1-2.pdf.aspx?lang=en-GB},
year = {2021}
}
TY - CONF
ID - 1809543
AU - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Kollár, Peter - Bobáľ, Pavel
PY - 2021
TI - Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates
KW - HDAC inhibitors Antiproliferative activity
UR - https://www.faf.cuni.cz/getattachment/Special/SAL2021/Program/SAD2021_Book-of-Abstracts_v1-2.pdf.aspx?lang=en-GB
N2 - Histone deacetylases (HDACs) have been long linked with tumor progression, demonstrating their important role in neoplasia. Inhibitors of HDAC (HDACI), which form a complex with Zn2+ ions in the active site of enzymes, are novel anticancer agents that induce tumor cell death, differentiation, and/or cell cycle arrest. We have designed and synthesized a series of N-hydroxycinnamamide derivates based on common HDAC`s pharmacophore with diversely substituted anilides.
ER -
ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR a Pavel BOBÁĽ. Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates. In \textit{49th Conference Synthesis and Analysis of Drugs}. 2021.
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