RUSINA, R., Lenka KRAJČOVIČOVÁ, B. SRPOVA and R. MATEJ. Metastatic intracranial spread of adenocarcinoma mimicking Creutzfeldt-Jakob disease in two cases. Revue neurologique. Paris: Elsevier Masson Editeur, 2021, vol. 177, No 8, p. 1006-1008. ISSN 0035-3787. Available from: https://dx.doi.org/10.1016/j.neurol.2020.12.009.
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Basic information
Original name Metastatic intracranial spread of adenocarcinoma mimicking Creutzfeldt-Jakob disease in two cases
Authors RUSINA, R. (203 Czech Republic, guarantor), Lenka KRAJČOVIČOVÁ (703 Slovakia, belonging to the institution), B. SRPOVA (203 Czech Republic) and R. MATEJ (203 Czech Republic).
Edition Revue neurologique, Paris, Elsevier Masson Editeur, 2021, 0035-3787.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher France
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.313
RIV identification code RIV/00216224:14110/21:00123240
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.neurol.2020.12.009
UT WoS 000717497200002
Keywords in English adenocarcinoma; Creutzfeldt-Jakob disease
Tags 14110127, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 13/12/2021 13:17.
Abstract
A 54-year-old female with a known pulmonary adenocarcinoma presented with rapid memory and language disturbances, she was anosognostic and apathetic with a Mini-Mental State Exam score 24/30. MRI showed parieto-occipital cortical ribboning in diffusion-weighted sequences (DWI) (Fig. 1A); cerebrospinal fluid (CSF) analysis found normal proteinorhachia (0,48 g/l), highly increased total tau (1481 ng/ml, N 116–370) and negative protein 14-3-3; testing for paraneoplastic antibodies (anti-Hu, Yo, Ri, CV2, PNMa2/Ta, amphiphysin) and antibodies associated with autoimmune limbic encephalitis (anti-NMDAR, AMPAR, CASPR2, LGI, GABABR) was negative. EEGs were nonspecific. Intravenous methylprednisolone and immunoglobulins were ineffective.
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