Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges

BOČKOVÁ, Martina and Ivan REKTOR. Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges. Journal of Neural Transmission. WIEN: SPRINGER WIEN, 2021, vol. 128, No 8, p. 1169-1175. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-021-02381-5.

Basic information

• Original name: Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges
• Authors: BOČKOVÁ, Martina (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2021, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30210 Clinical neurology
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.850
• RIV identification code: RIV/00216224:14740/21:00119422
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1007/s00702-021-02381-5
• UT WoS: 000671636200001
• Keywords in English: Deep brain stimulation; EEG biomarkers; Local field potentials; Movement disorders
• Tags: 14110127, podil, rivok
• Tags: International impact, Reviewed

Abstract

Several neurological diseases are accompanied by rhythmic oscillatory dysfunctions in various frequency ranges and disturbed cross-frequency relationships on regional, interregional, and whole brain levels. Knowledge of these disease-specific oscillopathies is important mainly in the context of deep brain stimulation (DBS) therapy. Electrophysiological biomarkers have been used as input signals for adaptive DBS (aDBS) as well as preoperative outcome predictors. As movement disorders, particularly Parkinson's disease (PD), are among the most frequent DBS indications, the current research of DBS is the most advanced in the movement disorders field. We reviewed the literature published mainly between 2010 and 2020 to identify the most important findings concerning the current evolution of electrophysiological biomarkers in DBS and to address future challenges for prospective research.

Links

• GA21-25953S, research and development project: Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)

Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective

• NU21-04-00445, research and development project: Name: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Acronym: DBScomorbidities)

Investor: Ministry of Health of the CR, STN-DBS outcomes in Parkinson´s disease: the influence of vascular, cardiovascular, metabolic, and inflammatory co-morbidities., Subprogram 1 - standard