Altered Spatiotemporal Dynamics of the Resting Brain in Mild
Cognitive Impairment with Lewy Bodies

J 2021

Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies

LAMOŠ, Martin, Ivona MORÁVKOVÁ, David ONDRÁČEK, Martina BOČKOVÁ, Irena REKTOROVÁ et. al.

Basic information

Original name

Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies

Authors

LAMOŠ, Martin (203 Czech Republic, belonging to the institution), Ivona MORÁVKOVÁ (703 Slovakia, belonging to the institution), David ONDRÁČEK (203 Czech Republic, belonging to the institution), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Movement Disorders, Hoboken, Wiley-Blackwell, 2021, 0885-3185

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 9.698

RIV identification code

RIV/00216224:14740/21:00120175

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1002/mds.28741

UT WoS

000680728300001

Keywords in English

EEG microstates; synucleinopathy; medication-naive; MCI-LB; prodromal DLB

Abstract

V originále

Background Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information. Objective To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker. Methods Temporal parameters of microstates were compared between 21 patients with mild cognitive impairment with Lewy bodies and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Results Microstates A-D showed higher occurrence in the patient group. Microstate B additionally revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. Conclusions Temporal dynamics of all EEG microstates were altered in medication-naive subjects with prodromal dementia with Lewy bodies. Longitudinal follow-up may reveal how EEG microstates reflect progression of brain function deficits and effects of treatment manipulations. (c) 2021 International Parkinson and Movement Disorder Society

Links

NU20-04-00294, research and development project

Name: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

LAMOŠ, Martin, Ivona MORÁVKOVÁ, David ONDRÁČEK, Martina BOČKOVÁ and Irena REKTOROVÁ. Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies. Movement Disorders. Hoboken: Wiley-Blackwell, 2021, vol. 36, No 10, p. 2435-2440. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.28741.

@article{1809880,
   author = {Lamoš, Martin and Morávková, Ivona and Ondráček, David and Bočková, Martina and Rektorová, Irena},
   article_location = {Hoboken},
   article_number = {10},
   doi = {http://dx.doi.org/10.1002/mds.28741},
   keywords = {EEG microstates; synucleinopathy; medication-naive; MCI-LB; prodromal DLB},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies},
   url = {https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28741},
   volume = {36},
   year = {2021}
}

TY  - JOUR
ID  - 1809880
AU  - Lamoš, Martin - Morávková, Ivona - Ondráček, David - Bočková, Martina - Rektorová, Irena
PY  - 2021
TI  - Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies
JF  - Movement Disorders
VL  - 36
IS  - 10
SP  - 2435-2440
EP  - 2435-2440
PB  - Wiley-Blackwell
SN  - 08853185
KW  - EEG microstates
KW  - synucleinopathy
KW  - medication-naive
KW  - MCI-LB
KW  - prodromal DLB
UR  - https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28741
N2  - Background Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information. Objective To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker. Methods Temporal parameters of microstates were compared between 21 patients with mild cognitive impairment with Lewy bodies and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Results Microstates A-D showed higher occurrence in the patient group. Microstate B additionally revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. Conclusions Temporal dynamics of all EEG microstates were altered in medication-naive subjects with prodromal dementia with Lewy bodies. Longitudinal follow-up may reveal how EEG microstates reflect progression of brain function deficits and effects of treatment manipulations. (c) 2021 International Parkinson and Movement Disorder Society
ER  -

LAMOŠ, Martin, Ivona MORÁVKOVÁ, David ONDRÁČEK, Martina BOČKOVÁ and Irena REKTOROVÁ. Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies. \textit{Movement Disorders}. Hoboken: Wiley-Blackwell, 2021, vol.~36, No~10, p.~2435-2440. ISSN~0885-3185. Available from: https://dx.doi.org/10.1002/mds.28741.

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