Detailed Information on Publication Record
2021
Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer - A Systematic Review
HUDEČKOVÁ, Markéta, Vladimír KOUCKÝ, Jan ROTTENBERG and Břetislav GÁLBasic information
Original name
Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer - A Systematic Review
Name in Czech
Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer - A Systematic Review
Authors
HUDEČKOVÁ, Markéta (203 Czech Republic, belonging to the institution), Vladimír KOUCKÝ (203 Czech Republic), Jan ROTTENBERG (203 Czech Republic, belonging to the institution) and Břetislav GÁL (203 Czech Republic, guarantor, belonging to the institution)
Edition
BIOMEDICINES, BASEL, MDPI, 2021, 2227-9059
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30206 Otorhinolaryngology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.757
RIV identification code
RIV/00216224:14110/21:00123265
Organization unit
Faculty of Medicine
UT WoS
000722923900001
Keywords (in Czech)
head and neck cancer squamous cell carcinoma (HNSCC); circulating tumour DNA (ctDNA); diagnostic biomarker; liquid biopsy
Keywords in English
head and neck cancer squamous cell carcinoma (HNSCC); circulating tumour DNA (ctDNA); diagnostic biomarker; liquid biopsy
Tags
International impact, Reviewed
Změněno: 17/5/2022 12:41, Mgr. Tereza Miškechová
V originále
Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. This review aims to provide an overview of ctDNA mutations in HNSCC patients and discuss the potential use of this tool in diagnosis and prognosis. (2) Methods: A systematic search for articles published in the English language between January 2000 and April 2021 in the Medline and Scopus databases was conducted. (3) Results: A total of 10 studies published in nine publications were selected and analysed. Altogether, 390 samples were obtained from HNSCC patients, and 79 control samples were evaluated. The most often explored gene mutation in ctDNA was TP53. (4) Conclusions: The examination of a larger group of gene mutations and the use of a combination of multiple detection methods contribute to a higher detection rate of mutated ctDNA. More studies are necessary to verify these conclusions and to translate them into clinical practice.
In Czech
Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. This review aims to provide an overview of ctDNA mutations in HNSCC patients and discuss the potential use of this tool in diagnosis and prognosis. (2) Methods: A systematic search for articles published in the English language between January 2000 and April 2021 in the Medline and Scopus databases was conducted. (3) Results: A total of 10 studies published in nine publications were selected and analysed. Altogether, 390 samples were obtained from HNSCC patients, and 79 control samples were evaluated. The most often explored gene mutation in ctDNA was TP53. (4) Conclusions: The examination of a larger group of gene mutations and the use of a combination of multiple detection methods contribute to a higher detection rate of mutated ctDNA. More studies are necessary to verify these conclusions and to translate them into clinical practice.
Links
| MUNI/A/1002/2018, interní kód MU |
|