Causes of Exocrine Pancreatic Insufficiency Other Than Chronic
Pancreatitis

J 2021

Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Michal EID, Karolina POREDSKÁ et. al.

Basic information

Original name

Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis

Authors

KUNOVSKÝ, Lumír (203 Czech Republic, belonging to the institution), Petr DÍTĚ (203 Czech Republic, belonging to the institution), Petr JABANDŽIEV (203 Czech Republic, belonging to the institution), Michal EID (203 Czech Republic, belonging to the institution), Karolina POREDSKÁ (203 Czech Republic, belonging to the institution), Jitka VACULOVÁ (203 Czech Republic, belonging to the institution), Dana SOCHOROVÁ (203 Czech Republic, belonging to the institution), Pavel JANEČEK (203 Czech Republic), Pavla TESAŘÍKOVÁ (203 Czech Republic), Martin BLAHO (203 Czech Republic), Jan TRNA (203 Czech Republic, belonging to the institution), Jan HLAVSA (203 Czech Republic, guarantor, belonging to the institution) and Zdeněk KALA (203 Czech Republic, belonging to the institution)

Edition

Journal of Clinical Medicine, Basel, MDPI, 2021, 2077-0383

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.964

RIV identification code

RIV/00216224:14110/21:00123325

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/jcm10245779

UT WoS

000737842000001

Keywords in English

exocrine pancreatic insufficiency; pancreatic enzyme replacement therapy; pancreatic cancer; cystic fibrosis; pancreatic resection; surgery; diabetes; celiac disease; inflammatory bowel disease; microbiome

Abstract

V originále

Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malnutrition, results from primary pancreatic disease or is secondary to impaired exocrine pancreatic function. Although chronic pancreatitis is the most common cause of EPI, several additional causes exist. These include pancreatic tumors, pancreatic resection procedures, and cystic fibrosis. Other diseases and conditions, such as diabetes mellitus, celiac disease, inflammatory bowel disease, and advanced patient age, have also been shown to be associated with EPI, but the exact etiology of EPI has not been clearly elucidated in these cases. The causes of EPI can be divided into loss of pancreatic parenchyma, inhibition or inactivation of pancreatic secretion, and postcibal pancreatic asynchrony. Pancreatic enzyme replacement therapy (PERT) is indicated for the conditions described above presenting with clinically clear steatorrhea, weight loss, or symptoms related to maldigestion and malabsorption. This review summarizes the current literature concerning those etiologies of EPI less common than chronic pancreatitis, the pathophysiology of the mechanisms of EPI associated with each diagnosis, and treatment recommendations.

Citovat

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Michal EID, Karolina POREDSKÁ, Jitka VACULOVÁ, Dana SOCHOROVÁ, Pavel JANEČEK, Pavla TESAŘÍKOVÁ, Martin BLAHO, Jan TRNA, Jan HLAVSA and Zdeněk KALA. Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis. Journal of Clinical Medicine. Basel: MDPI, 2021, vol. 10, No 24, p. 1-22. ISSN 2077-0383. Available from: https://dx.doi.org/10.3390/jcm10245779.

@article{1812479,
   author = {Kunovský, Lumír and Dítě, Petr and Jabandžiev, Petr and Eid, Michal and Poredská, Karolina and Vaculová, Jitka and Sochorová, Dana and Janeček, Pavel and Tesaříková, Pavla and Blaho, Martin and Trna, Jan and Hlavsa, Jan and Kala, Zdeněk},
   article_location = {Basel},
   article_number = {24},
   doi = {http://dx.doi.org/10.3390/jcm10245779},
   keywords = {exocrine pancreatic insufficiency; pancreatic enzyme replacement therapy; pancreatic cancer; cystic fibrosis; pancreatic resection; surgery; diabetes; celiac disease; inflammatory bowel disease; microbiome},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis},
   url = {https://www.mdpi.com/2077-0383/10/24/5779#cite},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1812479
AU  - Kunovský, Lumír - Dítě, Petr - Jabandžiev, Petr - Eid, Michal - Poredská, Karolina - Vaculová, Jitka - Sochorová, Dana - Janeček, Pavel - Tesaříková, Pavla - Blaho, Martin - Trna, Jan - Hlavsa, Jan - Kala, Zdeněk
PY  - 2021
TI  - Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis
JF  - Journal of Clinical Medicine
VL  - 10
IS  - 24
SP  - 1-22
EP  - 1-22
PB  - MDPI
SN  - 20770383
KW  - exocrine pancreatic insufficiency
KW  - pancreatic enzyme replacement therapy
KW  - pancreatic cancer
KW  - cystic fibrosis
KW  - pancreatic resection
KW  - surgery
KW  - diabetes
KW  - celiac disease
KW  - inflammatory bowel disease
KW  - microbiome
UR  - https://www.mdpi.com/2077-0383/10/24/5779#cite
N2  - Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malnutrition, results from primary pancreatic disease or is secondary to impaired exocrine pancreatic function. Although chronic pancreatitis is the most common cause of EPI, several additional causes exist. These include pancreatic tumors, pancreatic resection procedures, and cystic fibrosis. Other diseases and conditions, such as diabetes mellitus, celiac disease, inflammatory bowel disease, and advanced patient age, have also been shown to be associated with EPI, but the exact etiology of EPI has not been clearly elucidated in these cases. The causes of EPI can be divided into loss of pancreatic parenchyma, inhibition or inactivation of pancreatic secretion, and postcibal pancreatic asynchrony. Pancreatic enzyme replacement therapy (PERT) is indicated for the conditions described above presenting with clinically clear steatorrhea, weight loss, or symptoms related to maldigestion and malabsorption. This review summarizes the current literature concerning those etiologies of EPI less common than chronic pancreatitis, the pathophysiology of the mechanisms of EPI associated with each diagnosis, and treatment recommendations.
ER  -

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Michal EID, Karolina POREDSKÁ, Jitka VACULOVÁ, Dana SOCHOROVÁ, Pavel JANEČEK, Pavla TESAŘÍKOVÁ, Martin BLAHO, Jan TRNA, Jan HLAVSA and Zdeněk KALA. Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, vol.~10, No~24, p.~1-22. ISSN~2077-0383. Available from: https://dx.doi.org/10.3390/jcm10245779.

Detailed Information on Publication Record