Generic acquisition protocol for quantitative MRI of the spinal cord
Authors
COHEN-ADAD, Julien (guarantor), Eva ALONSO-ORTIZ, Mihael ABRAMOVIC, Carina ARNEITZ, Nicole ATCHESON, Laura BARLOW, Robert L BARRY, Markus BARTH, Marco BATTISTON, Christian BÜCHEL, Matthew BUDDE, Virginie CALLOT, Anna J E COMBES, Benjamin De LEENER, Maxime DESCOTEAUX, Paulo Loureiro de SOUSA, Marek DOSTÁL (203 Czech Republic, belonging to the institution), Julien DOYON, Adam DVORAK, Falk EIPPERT, Karla R EPPERSON, Kevin S EPPERSON, Patrick FREUND, Jürgen FINSTERBUSCH, Alexandru FOIAS, Michela FRATINI, Issei FUKUNAGA, Claudia A M Gandini WHEELER-KINGSHOTT, Giancarlo GERMANI, Guillaume GILBERT, Federico GIOVE, Charley GROS, Francesco GRUSSU, Akifumi HAGIWARA, Pierre-Gilles HENRY, Tomáš HORÁK (203 Czech Republic, belonging to the institution), Masaaki HORI, James JOERS, Kouhei KAMIYA, Haleh KARBASFOROUSHAN, Miloš KEŘKOVSKÝ (203 Czech Republic, belonging to the institution), Ali KHATIBI, Joo-Won KIM, Nawal KINANY, Hagen KITZLER, Shannon KOLIND, Yazhuo KONG, Petr KUDLIČKA (203 Czech Republic, belonging to the institution), Paul KUNTKE, Nyoman D KURNIAWAN, Slawomir KUSMIA, René LABOUNEK, Maria Marcella LAGANÀ, Cornelia LAULE, Christine S LAW, Christophe LENGLET, Tobias LEUTRITZ, Yaou LIU, Sara LLUFRIU, Sean MACKEY, Eloy MARTINEZ-HERAS, Loan MATTERA, Igor NESTRASIL, Kristin P O GRADY, Nico PAPINUTTO, Daniel PAPP, Deborah PARETO, Todd B PARRISH, Anna PICHIECCHIO, Ferran PRADOS, Àlex ROVIRA, Marc J RUITENBERG, Rebecca S SAMSON, Giovanni SAVINI, Maryam SEIF, Alan C SEIFERT, Alex K SMITH, Seth A SMITH, Zachary A SMITH, Elisabeth SOLANA, Yuichi SUZUKI, George TACKLEY, Alexandra TINNERMANN, Jan VALOŠEK, Dimitri Van De VILLE, Marios C YIANNAKAS, Kenneth A Weber II, Nikolaus WEISKOPF, Richard G WISE, Patrik O WYSS and Junqian XU
Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/ protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.
Links
NV18-04-00159, research and development project
Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy
Investor: Ministry of Health of the CR
681094, interní kód MU
Name: NISCI - Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European randomized double blinded placebo controlled phase II clinical proof of concept trial (Acronym: NISCI)
Investor: European Union, Health, demographic change and wellbeing (Societal Challenges)
COHEN-ADAD, Julien, Eva ALONSO-ORTIZ, Mihael ABRAMOVIC, Carina ARNEITZ, Nicole ATCHESON, Laura BARLOW, Robert L BARRY, Markus BARTH, Marco BATTISTON, Christian BÜCHEL, Matthew BUDDE, Virginie CALLOT, Anna J E COMBES, Benjamin De LEENER, Maxime DESCOTEAUX, Paulo Loureiro de SOUSA, Marek DOSTÁL, Julien DOYON, Adam DVORAK, Falk EIPPERT, Karla R EPPERSON, Kevin S EPPERSON, Patrick FREUND, Jürgen FINSTERBUSCH, Alexandru FOIAS, Michela FRATINI, Issei FUKUNAGA, Claudia A M Gandini WHEELER-KINGSHOTT, Giancarlo GERMANI, Guillaume GILBERT, Federico GIOVE, Charley GROS, Francesco GRUSSU, Akifumi HAGIWARA, Pierre-Gilles HENRY, Tomáš HORÁK, Masaaki HORI, James JOERS, Kouhei KAMIYA, Haleh KARBASFOROUSHAN, Miloš KEŘKOVSKÝ, Ali KHATIBI, Joo-Won KIM, Nawal KINANY, Hagen KITZLER, Shannon KOLIND, Yazhuo KONG, Petr KUDLIČKA, Paul KUNTKE, Nyoman D KURNIAWAN, Slawomir KUSMIA, René LABOUNEK, Maria Marcella LAGANÀ, Cornelia LAULE, Christine S LAW, Christophe LENGLET, Tobias LEUTRITZ, Yaou LIU, Sara LLUFRIU, Sean MACKEY, Eloy MARTINEZ-HERAS, Loan MATTERA, Igor NESTRASIL, Kristin P O GRADY, Nico PAPINUTTO, Daniel PAPP, Deborah PARETO, Todd B PARRISH, Anna PICHIECCHIO, Ferran PRADOS, Àlex ROVIRA, Marc J RUITENBERG, Rebecca S SAMSON, Giovanni SAVINI, Maryam SEIF, Alan C SEIFERT, Alex K SMITH, Seth A SMITH, Zachary A SMITH, Elisabeth SOLANA, Yuichi SUZUKI, George TACKLEY, Alexandra TINNERMANN, Jan VALOŠEK, Dimitri Van De VILLE, Marios C YIANNAKAS, Kenneth A Weber II, Nikolaus WEISKOPF, Richard G WISE, Patrik O WYSS and Junqian XU. Generic acquisition protocol for quantitative MRI of the spinal cord. Nature Protocols. Berlin: Nature Research, 2021, vol. 16, No 10, p. 4611-4632. ISSN 1754-2189. Available from: https://dx.doi.org/10.1038/s41596-021-00588-0.
@article{1812587, author = {CohenandAdad, Julien and AlonsoandOrtiz, Eva and Abramovic, Mihael and Arneitz, Carina and Atcheson, Nicole and Barlow, Laura and Barry, Robert L and Barth, Markus and Battiston, Marco and Büchel, Christian and Budde, Matthew and Callot, Virginie and Combes, Anna J E and Leener, Benjamin De and Descoteaux, Maxime and Sousa, Paulo Loureiro de and Dostál, Marek and Doyon, Julien and Dvorak, Adam and Eippert, Falk and Epperson, Karla R and Epperson, Kevin S and Freund, Patrick and Finsterbusch, Jürgen and Foias, Alexandru and Fratini, Michela and Fukunaga, Issei and WheelerandKingshott, Claudia A M Gandini and Germani, Giancarlo and Gilbert, Guillaume and Giove, Federico and Gros, Charley and Grussu, Francesco and Hagiwara, Akifumi and Henry, PierreandGilles and Horák, Tomáš and Hori, Masaaki and Joers, James and Kamiya, Kouhei and Karbasforoushan, Haleh and Keřkovský, Miloš and Khatibi, Ali and Kim, JooandWon and Kinany, Nawal and Kitzler, Hagen and Kolind, Shannon and Kong, Yazhuo and Kudlička, Petr and Kuntke, Paul and Kurniawan, Nyoman D and Kusmia, Slawomir and Labounek, René and Laganà, Maria Marcella and Laule, Cornelia and Law, Christine S and Lenglet, Christophe and Leutritz, Tobias and Liu, Yaou and Llufriu, Sara and Mackey, Sean and MartinezandHeras, Eloy and Mattera, Loan and Nestrasil, Igor and Grady, Kristin P O and Papinutto, Nico and Papp, Daniel and Pareto, Deborah and Parrish, Todd B and Pichiecchio, Anna and Prados, Ferran and Rovira, Àlex and Ruitenberg, Marc J and Samson, Rebecca S and Savini, Giovanni and Seif, Maryam and Seifert, Alan C and Smith, Alex K and Smith, Seth A and Smith, Zachary A and Solana, Elisabeth and Suzuki, Yuichi and Tackley, George and Tinnermann, Alexandra and Valošek, Jan and Ville, Dimitri Van De and Yiannakas, Marios C and II, Kenneth A Weber and Weiskopf, Nikolaus and Wise, Richard G and Wyss, Patrik O and Xu, Junqian}, article_location = {Berlin}, article_number = {10}, doi = {http://dx.doi.org/10.1038/s41596-021-00588-0}, keywords = {quantitative MRI; spinal cord}, language = {eng}, issn = {1754-2189}, journal = {Nature Protocols}, title = {Generic acquisition protocol for quantitative MRI of the spinal cord}, url = {https://www.nature.com/articles/s41596-021-00588-0}, volume = {16}, year = {2021} }
TY - JOUR ID - 1812587 AU - Cohen-Adad, Julien - Alonso-Ortiz, Eva - Abramovic, Mihael - Arneitz, Carina - Atcheson, Nicole - Barlow, Laura - Barry, Robert L - Barth, Markus - Battiston, Marco - Büchel, Christian - Budde, Matthew - Callot, Virginie - Combes, Anna J E - Leener, Benjamin De - Descoteaux, Maxime - Sousa, Paulo Loureiro de - Dostál, Marek - Doyon, Julien - Dvorak, Adam - Eippert, Falk - Epperson, Karla R - Epperson, Kevin S - Freund, Patrick - Finsterbusch, Jürgen - Foias, Alexandru - Fratini, Michela - Fukunaga, Issei - Wheeler-Kingshott, Claudia A M Gandini - Germani, Giancarlo - Gilbert, Guillaume - Giove, Federico - Gros, Charley - Grussu, Francesco - Hagiwara, Akifumi - Henry, Pierre-Gilles - Horák, Tomáš - Hori, Masaaki - Joers, James - Kamiya, Kouhei - Karbasforoushan, Haleh - Keřkovský, Miloš - Khatibi, Ali - Kim, Joo-Won - Kinany, Nawal - Kitzler, Hagen - Kolind, Shannon - Kong, Yazhuo - Kudlička, Petr - Kuntke, Paul - Kurniawan, Nyoman D - Kusmia, Slawomir - Labounek, René - Laganà, Maria Marcella - Laule, Cornelia - Law, Christine S - Lenglet, Christophe - Leutritz, Tobias - Liu, Yaou - Llufriu, Sara - Mackey, Sean - Martinez-Heras, Eloy - Mattera, Loan - Nestrasil, Igor - Grady, Kristin P O - Papinutto, Nico - Papp, Daniel - Pareto, Deborah - Parrish, Todd B - Pichiecchio, Anna - Prados, Ferran - Rovira, Àlex - Ruitenberg, Marc J - Samson, Rebecca S - Savini, Giovanni - Seif, Maryam - Seifert, Alan C - Smith, Alex K - Smith, Seth A - Smith, Zachary A - Solana, Elisabeth - Suzuki, Yuichi - Tackley, George - Tinnermann, Alexandra - Valošek, Jan - Ville, Dimitri Van De - Yiannakas, Marios C - II, Kenneth A Weber - Weiskopf, Nikolaus - Wise, Richard G - Wyss, Patrik O - Xu, Junqian PY - 2021 TI - Generic acquisition protocol for quantitative MRI of the spinal cord JF - Nature Protocols VL - 16 IS - 10 SP - 4611-4632 EP - 4611-4632 PB - Nature Research SN - 17542189 KW - quantitative MRI KW - spinal cord UR - https://www.nature.com/articles/s41596-021-00588-0 N2 - Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/ protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition. ER -
COHEN-ADAD, Julien, Eva ALONSO-ORTIZ, Mihael ABRAMOVIC, Carina ARNEITZ, Nicole ATCHESON, Laura BARLOW, Robert L BARRY, Markus BARTH, Marco BATTISTON, Christian BÜCHEL, Matthew BUDDE, Virginie CALLOT, Anna J E COMBES, Benjamin De LEENER, Maxime DESCOTEAUX, Paulo Loureiro de SOUSA, Marek DOSTÁL, Julien DOYON, Adam DVORAK, Falk EIPPERT, Karla R EPPERSON, Kevin S EPPERSON, Patrick FREUND, Jürgen FINSTERBUSCH, Alexandru FOIAS, Michela FRATINI, Issei FUKUNAGA, Claudia A M Gandini WHEELER-KINGSHOTT, Giancarlo GERMANI, Guillaume GILBERT, Federico GIOVE, Charley GROS, Francesco GRUSSU, Akifumi HAGIWARA, Pierre-Gilles HENRY, Tomáš HORÁK, Masaaki HORI, James JOERS, Kouhei KAMIYA, Haleh KARBASFOROUSHAN, Miloš KEŘKOVSKÝ, Ali KHATIBI, Joo-Won KIM, Nawal KINANY, Hagen KITZLER, Shannon KOLIND, Yazhuo KONG, Petr KUDLIČKA, Paul KUNTKE, Nyoman D KURNIAWAN, Slawomir KUSMIA, René LABOUNEK, Maria Marcella LAGANÀ, Cornelia LAULE, Christine S LAW, Christophe LENGLET, Tobias LEUTRITZ, Yaou LIU, Sara LLUFRIU, Sean MACKEY, Eloy MARTINEZ-HERAS, Loan MATTERA, Igor NESTRASIL, Kristin P O GRADY, Nico PAPINUTTO, Daniel PAPP, Deborah PARETO, Todd B PARRISH, Anna PICHIECCHIO, Ferran PRADOS, Àlex ROVIRA, Marc J RUITENBERG, Rebecca S SAMSON, Giovanni SAVINI, Maryam SEIF, Alan C SEIFERT, Alex K SMITH, Seth A SMITH, Zachary A SMITH, Elisabeth SOLANA, Yuichi SUZUKI, George TACKLEY, Alexandra TINNERMANN, Jan VALOŠEK, Dimitri Van De VILLE, Marios C YIANNAKAS, Kenneth A Weber II, Nikolaus WEISKOPF, Richard G WISE, Patrik O WYSS and Junqian XU. Generic acquisition protocol for quantitative MRI of the spinal cord. \textit{Nature Protocols}. Berlin: Nature Research, 2021, vol.~16, No~10, p.~4611-4632. ISSN~1754-2189. Available from: https://dx.doi.org/10.1038/s41596-021-00588-0.