Detailed Information on Publication Record
2021
CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients
PEKAŘOVÁ, Anna, Matej PEKAŘ, Daniel DANIŠ and Zuzana NOVÁKOVÁBasic information
Original name
CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients
Authors
PEKAŘOVÁ, Anna (203 Czech Republic, belonging to the institution), Matej PEKAŘ (703 Slovakia, guarantor, belonging to the institution), Daniel DANIŠ (703 Slovakia) and Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Physiological Research, Praha, Institute of Physiology, Academy of Sci, 2021, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30203 Respiratory systems
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.139
RIV identification code
RIV/00216224:14110/21:00123367
Organization unit
Faculty of Medicine
UT WoS
000755158200012
Keywords in English
small cell lung cancer; survival; sarcopenia; psoas muscle density; abdominal muscle area
Tags
International impact, Reviewed
Změněno: 17/5/2022 12:42, Mgr. Tereza Miškechová
Abstract
V originále
Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman ' s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05 +/- 7.3 years, BMI 23.97 +/- 4.4 kg/m(2) , BSA 1.77 +/- 0.2 m(2) , 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm(2)/m(2) for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman ' s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49 +/- 6.1 vs. 47.67 +/- 4.5 HU, p=0.006) between ED vs. LD groups.
Links
| MUNI/A/1246/2020, interní kód MU |
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