| MANČÍKOVÁ, Veronika and Michal ŠMÍDA. Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol. 22, No 11, p. 5536-5546. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms22115536. |
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@article{1813385,
author = {Mančíková, Veronika and Šmída, Michal},
article_location = {Basel},
article_number = {11},
doi = {http://dx.doi.org/10.3390/ijms22115536},
keywords = {chimeric antigen receptor; immunotherapy; chronic lymphocytic leukemia; CD19},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia},
url = {https://www.mdpi.com/1422-0067/22/11/5536},
volume = {22},
year = {2021}
}
TY - JOUR
ID - 1813385
AU - Mančíková, Veronika - Šmída, Michal
PY - 2021
TI - Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia
JF - International Journal of Molecular Sciences
VL - 22
IS - 11
SP - 5536
EP - 5536
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - chimeric antigen receptor
KW - immunotherapy
KW - chronic lymphocytic leukemia
KW - CD19
UR - https://www.mdpi.com/1422-0067/22/11/5536
N2 - Chimeric antigen receptor (CAR) T-cell therapy has already achieved remarkable remissions in some difficult-to-treat patients with B-cell malignancies. Although the clinical experience in chronic lymphocytic leukemia (CLL) patients is limited, the proportion of remissions reached in this disease is clearly the lowest from the spectrum of B-cell tumors. In this review, we discuss the antigenic targets exploited in CLL CAR-T therapy, the determinants of favorable responses, as well as the mechanisms of treatment failure specific to this disease.
ER -
MANČÍKOVÁ, Veronika and Michal ŠMÍDA. Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol.~22, No~11, p.~5536-5546. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms22115536.
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