MANČÍKOVÁ, Veronika and Michal ŠMÍDA. Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol. 22, No 11, p. 5536-5546. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms22115536. |
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@article{1813385, author = {Mančíková, Veronika and Šmída, Michal}, article_location = {Basel}, article_number = {11}, doi = {http://dx.doi.org/10.3390/ijms22115536}, keywords = {chimeric antigen receptor; immunotherapy; chronic lymphocytic leukemia; CD19}, language = {eng}, issn = {1422-0067}, journal = {International Journal of Molecular Sciences}, title = {Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia}, url = {https://www.mdpi.com/1422-0067/22/11/5536}, volume = {22}, year = {2021} }
TY - JOUR ID - 1813385 AU - Mančíková, Veronika - Šmída, Michal PY - 2021 TI - Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia JF - International Journal of Molecular Sciences VL - 22 IS - 11 SP - 5536 EP - 5536 PB - Multidisciplinary Digital Publishing Institute SN - 14220067 KW - chimeric antigen receptor KW - immunotherapy KW - chronic lymphocytic leukemia KW - CD19 UR - https://www.mdpi.com/1422-0067/22/11/5536 N2 - Chimeric antigen receptor (CAR) T-cell therapy has already achieved remarkable remissions in some difficult-to-treat patients with B-cell malignancies. Although the clinical experience in chronic lymphocytic leukemia (CLL) patients is limited, the proportion of remissions reached in this disease is clearly the lowest from the spectrum of B-cell tumors. In this review, we discuss the antigenic targets exploited in CLL CAR-T therapy, the determinants of favorable responses, as well as the mechanisms of treatment failure specific to this disease. ER -
MANČÍKOVÁ, Veronika and Michal ŠMÍDA. Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol.~22, No~11, p.~5536-5546. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms22115536.
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