Global profiling of microRNA expression in brain metastases

a 2021

Global profiling of microRNA expression in brain metastases

SMRČKA, Martin, Marek VEČEŘA, Lenka RADOVÁ, Simona SIDOROVÁ, František SIEGL et. al.

Basic information

Original name

Global profiling of microRNA expression in brain metastases

Authors

SMRČKA, Martin (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Lenka RADOVÁ (203 Czech Republic, belonging to the institution), Simona SIDOROVÁ (703 Slovakia, belonging to the institution), František SIEGL (203 Czech Republic, belonging to the institution), Radim JANČÁLEK (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, belonging to the institution)

Edition

Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti, 2021

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30212 Surgery

Country of publisher

Ukraine

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/21:00120189

Organization unit

Faculty of Medicine

Keywords in English

brain metastases; microRNA

Abstract

V originále

Brain metastases (BM) are the most common intracranial tumors occurring in 20-40% of adult cancer patients. BM have long received little attention and, in general, symptomatic palliative care has been indicated without attempting to significantly prolong overall survival (OS). The current approach to BM treatment is changing as the incidence increases over time because of more effective treatment of primary tumors prolonging OS, as well as improved imaging to detect smaller asymptomatic BM. Although the survival of patients with BM is generally unfavorable, the prognosis individually varies significantly. Therefore, it would be useful to strengthen prognostic tools with new high-performance molecular markers. Particularly promising are microRNAs (miRNAs), non-coding RNAs with the length of 18-25 nt, which post-transcriptionally regulate gene expression by silencing mRNA targets. They are stable and thus suitable for sequencing and retrospective analyses in FFPE tissues. Although dysregulated expression (DE) and diagnostic potential of miRNAs have been described in tumors, including BM, there is only a handful of studies describing global miRNA expression profiling in BM and their association with OS.

Links

NV18-03-00398, research and development project

Name: Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

Investor: Ministry of Health of the CR, Extension of established prognostic scores in brain metastases by microRNA profiling to tailor the post-operative personalized care

Citovat

SMRČKA, Martin, Marek VEČEŘA, Lenka RADOVÁ, Simona SIDOROVÁ, František SIEGL, Radim JANČÁLEK, Markéta HERMANOVÁ, Leoš KŘEN, Jiří ŠÁNA and Ondřej SLABÝ. Global profiling of microRNA expression in brain metastases. In Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti. 2021.

@proceedings{1814117,
   author = {Smrčka, Martin and Večeřa, Marek and Radová, Lenka and Sidorová, Simona and Siegl, František and Jančálek, Radim and Hermanová, Markéta and Křen, Leoš and Šána, Jiří and Slabý, Ondřej},
   booktitle = {Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti},
   keywords = {brain metastases; microRNA},
   language = {eng},
   title = {Global profiling of microRNA expression in brain metastases},
   year = {2021}
}

TY  - CONF
ID  - 1814117
AU  - Smrčka, Martin - Večeřa, Marek - Radová, Lenka - Sidorová, Simona - Siegl, František - Jančálek, Radim - Hermanová, Markéta - Křen, Leoš - Šána, Jiří - Slabý, Ondřej
PY  - 2021
TI  - Global profiling of microRNA expression in brain metastases
KW  - brain metastases
KW  - microRNA
N2  - Brain metastases (BM) are the most common intracranial tumors occurring in 20-40% of adult cancer patients. BM have long received little attention and, in general, symptomatic palliative care has been indicated without attempting to significantly prolong overall survival (OS). The current approach to BM treatment is changing as the incidence increases over time because of more effective treatment of primary tumors prolonging OS, as well as improved imaging to detect smaller asymptomatic BM. Although the survival of patients with BM is generally unfavorable, the prognosis individually varies significantly. Therefore, it would be useful to strengthen prognostic tools with new high-performance molecular markers. Particularly promising are microRNAs (miRNAs), non-coding RNAs with the length of 18-25 nt, which post-transcriptionally regulate gene expression by silencing mRNA targets. They are stable and thus suitable for sequencing and retrospective analyses in FFPE tissues. Although dysregulated expression (DE) and diagnostic potential of miRNAs have been described in tumors, including BM, there is only a handful of studies describing global miRNA expression profiling in BM and their association with OS.
ER  -

SMRČKA, Martin, Marek VEČEŘA, Lenka RADOVÁ, Simona SIDOROVÁ, František SIEGL, Radim JANČÁLEK, Markéta HERMANOVÁ, Leoš KŘEN, Jiří ŠÁNA and Ondřej SLABÝ. Global profiling of microRNA expression in brain metastases. In \textit{Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti}. 2021.

Detailed Information on Publication Record