a 2021

Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?

SIEGL, František, Marek VEČEŘA, Karolína TRACHTOVÁ, Dagmar AL TUKMACHI, Petr BUŠEK et. al.

Basic information

Original name

Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?

Authors

SIEGL, František (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Karolína TRACHTOVÁ (203 Czech Republic, belonging to the institution), Dagmar AL TUKMACHI (203 Czech Republic, belonging to the institution), Petr BUŠEK (203 Czech Republic), Pavel FADRUS (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Jiří ŠÁNA (203 Czech Republic, belonging to the institution)

Edition

Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti, 2021

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30212 Surgery

Country of publisher

Ukraine

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/21:00120190

Organization unit

Faculty of Medicine

Keywords in English

glioblastoma; PIWI-interacting RNAs

Tags

Tags

International impact
Změněno: 3/1/2022 09:56, Mgr. Tereza Miškechová

Abstract

V originále

Glioblastoma (GBM) is the most common malignant brain tumor of astrocytic origin. Despite the radical therapy, relapse is a common and relatively early event, with the major mechanism possibly being the presence of glioblastoma stem cells (GSC), able to withstand the therapy and to establish new GBM deposits. PIWI-interacting RNAs (piRNA) may have a key role in GSC biology, which are physiologically responsible for the genome stability maintenance in germ and stem cells. Nevertheless, their dysregulation was observed in cancers, including GBM. Identification of GSC-specific piRNA molecules could lead to distinguishing GSC from their differentiated counterparts (non-GSC), enabling their therapeutic targeting.

Links

NV19-03-00501, research and development project
Name: Studium PIWI-interagujících RNA u glioblastomových kmenových buněk a jejich možné klinické implikace
Investor: Ministry of Health of the CR, Study of PIWI-interacting RNAs in glioblastoma stem cells and their potential clinical implications