Detailed Information on Publication Record
2021
Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?
SIEGL, František, Marek VEČEŘA, Karolína TRACHTOVÁ, Dagmar AL TUKMACHI, Petr BUŠEK et. al.Basic information
Original name
Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?
Authors
SIEGL, František (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Karolína TRACHTOVÁ (203 Czech Republic, belonging to the institution), Dagmar AL TUKMACHI (203 Czech Republic, belonging to the institution), Petr BUŠEK (203 Czech Republic), Pavel FADRUS (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Jiří ŠÁNA (203 Czech Republic, belonging to the institution)
Edition
Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti, 2021
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30212 Surgery
Country of publisher
Ukraine
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/21:00120190
Organization unit
Faculty of Medicine
Keywords in English
glioblastoma; PIWI-interacting RNAs
Tags
Tags
International impact
Změněno: 3/1/2022 09:56, Mgr. Tereza Miškechová
Abstract
V originále
Glioblastoma (GBM) is the most common malignant brain tumor of astrocytic origin. Despite the radical therapy, relapse is a common and relatively early event, with the major mechanism possibly being the presence of glioblastoma stem cells (GSC), able to withstand the therapy and to establish new GBM deposits. PIWI-interacting RNAs (piRNA) may have a key role in GSC biology, which are physiologically responsible for the genome stability maintenance in germ and stem cells. Nevertheless, their dysregulation was observed in cancers, including GBM. Identification of GSC-specific piRNA molecules could lead to distinguishing GSC from their differentiated counterparts (non-GSC), enabling their therapeutic targeting.
Links
NV19-03-00501, research and development project |
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