SIEGL, František, Marek VEČEŘA, Karolína TRACHTOVÁ, Dagmar AL TUKMACHI, Petr BUŠEK, Pavel FADRUS, Martin SMRČKA, Ondřej SLABÝ and Jiří ŠÁNA. Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation? In Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti. 2021.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?
Authors SIEGL, František (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Karolína TRACHTOVÁ (203 Czech Republic, belonging to the institution), Dagmar AL TUKMACHI (203 Czech Republic, belonging to the institution), Petr BUŠEK (203 Czech Republic), Pavel FADRUS (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Jiří ŠÁNA (203 Czech Republic, belonging to the institution).
Edition Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti, 2021.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30212 Surgery
Country of publisher Ukraine
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/21:00120190
Organization unit Faculty of Medicine
Keywords in English glioblastoma; PIWI-interacting RNAs
Tags rivok
Tags International impact
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 3/1/2022 09:56.
Abstract
Glioblastoma (GBM) is the most common malignant brain tumor of astrocytic origin. Despite the radical therapy, relapse is a common and relatively early event, with the major mechanism possibly being the presence of glioblastoma stem cells (GSC), able to withstand the therapy and to establish new GBM deposits. PIWI-interacting RNAs (piRNA) may have a key role in GSC biology, which are physiologically responsible for the genome stability maintenance in germ and stem cells. Nevertheless, their dysregulation was observed in cancers, including GBM. Identification of GSC-specific piRNA molecules could lead to distinguishing GSC from their differentiated counterparts (non-GSC), enabling their therapeutic targeting.
Links
NV19-03-00501, research and development projectName: Studium PIWI-interagujících RNA u glioblastomových kmenových buněk a jejich možné klinické implikace
Investor: Ministry of Health of the CR, Study of PIWI-interacting RNAs in glioblastoma stem cells and their potential clinical implications
PrintDisplayed: 18/7/2024 14:33