| GONĚC, Tomáš, Hana MICHNOVÁ, Kateřina KLEINEROVÁ, Gabriela BUČKOVÁ, Alois ČÍŽEK and Josef JAMPÍLEK. SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA. In 49th Conference Synthesis and Analysis of Drugs 2021 Hradec Králové. 2021. |
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@proceedings{1815803,
author = {Goněc, Tomáš and Michnová, Hana and Kleinerová, Kateřina and Bučková, Gabriela and Čížek, Alois and Jampílek, Josef},
booktitle = {49th Conference Synthesis and Analysis of Drugs 2021 Hradec Králové},
keywords = {synthesis; antimicrobial; MRSA},
language = {eng},
title = {SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA},
url = {https://www.faf.cuni.cz/getattachment/Special/SAL2021/Program/SAD2021_Book-of-Abstracts_v1-2.pdf.aspx?lang=en-GB},
year = {2021}
}
TY - CONF
ID - 1815803
AU - Goněc, Tomáš - Michnová, Hana - Kleinerová, Kateřina - Bučková, Gabriela - Čížek, Alois - Jampílek, Josef
PY - 2021
TI - SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA
KW - synthesis
KW - antimicrobial
KW - MRSA
UR - https://www.faf.cuni.cz/getattachment/Special/SAL2021/Program/SAD2021_Book-of-Abstracts_v1-2.pdf.aspx?lang=en-GB
N2 - Recently, we have synthesized novel series of N-phenylhydroxynaphthalene carboxamides possessing promising antimicrobial activities. Introduction of alkylcarbamate moiety lead to enhancement of physical-chemical properties (especially of solubility) and the biological activity was preserved. Series of 13 novel compounds was synthesized and evaluated for antimicrobial activity. Preliminary results showed that all compounds have comparable or much better MIC than standards ciprofloxacin and ampicillin. Best compounds showed MIC in a range of few nM.
ER -
GONĚC, Tomáš, Hana MICHNOVÁ, Kateřina KLEINEROVÁ, Gabriela BUČKOVÁ, Alois ČÍŽEK and Josef JAMPÍLEK. SYNTHESIS OF NOVEL 2-(PHENYLCARBAMOYL)NAPHTHALENE-1-YL ALKYLCARBAMATES POSSESSING EXCELLENT ANTIMICROBIAL ACTIVITY AGAINST MRSA. In \textit{49th Conference Synthesis and Analysis of Drugs 2021 Hradec Králové}. 2021.
|
