Epileptogenic zone detection in MRI negative epilepsy using
adaptive thresholding of arterial spin labeling data

J 2021

Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

GAJDOŠ, Martin, Pavel ŘÍHA, Martin KOJAN, Irena DOLEŽALOVÁ, H.J.M.M. MUTSAERTS et. al.

Basic information

Original name

Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

Authors

GAJDOŠ, Martin (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Martin KOJAN (703 Slovakia, belonging to the institution), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), H.J.M.M. MUTSAERTS, J. PETR and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Nature Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.996

RIV identification code

RIV/00216224:14740/21:00120198

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41598-021-89774-4

UT WoS

000659135700033

Keywords in English

TEMPORAL-LOBE EPILEPSY; CONSENSUS CLASSIFICATION; TASK-FORCE; PERFUSION; HYPOPERFUSION

Abstract

V originále

Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 +/- 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.

Links

LM2018129, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

NV17-32292A, research and development project

Name: Detekce léze u nelezionální epilepsie s využitím multimodálního zobrazování

Citovat

GAJDOŠ, Martin, Pavel ŘÍHA, Martin KOJAN, Irena DOLEŽALOVÁ, H.J.M.M. MUTSAERTS, J. PETR and Ivan REKTOR. Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data. Nature Scientific Reports. London: NATURE RESEARCH, 2021, vol. 11, No 1, p. 10904-10909. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-89774-4.

@article{1816718,
   author = {Gajdoš, Martin and Říha, Pavel and Kojan, Martin and Doležalová, Irena and Mutsaerts, H.J.M.M. and Petr, J. and Rektor, Ivan},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-021-89774-4},
   keywords = {TEMPORAL-LOBE EPILEPSY; CONSENSUS CLASSIFICATION; TASK-FORCE; PERFUSION; HYPOPERFUSION},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data},
   url = {https://www.nature.com/articles/s41598-021-89774-4.pdf},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1816718
AU  - Gajdoš, Martin - Říha, Pavel - Kojan, Martin - Doležalová, Irena - Mutsaerts, H.J.M.M. - Petr, J. - Rektor, Ivan
PY  - 2021
TI  - Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
JF  - Nature Scientific Reports
VL  - 11
IS  - 1
SP  - 10904
EP  - 10904
PB  - NATURE RESEARCH
SN  - 20452322
KW  - TEMPORAL-LOBE EPILEPSY
KW  - CONSENSUS CLASSIFICATION
KW  - TASK-FORCE
KW  - PERFUSION
KW  - HYPOPERFUSION
UR  - https://www.nature.com/articles/s41598-021-89774-4.pdf
N2  - Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 +/- 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.
ER  -

GAJDOŠ, Martin, Pavel ŘÍHA, Martin KOJAN, Irena DOLEŽALOVÁ, H.J.M.M. MUTSAERTS, J. PETR and Ivan REKTOR. Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, vol.~11, No~1, p.~10904-10909. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-89774-4.

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