BACCI, Sabrina, Nathalie NICOLAY, Ester KISSLING, Anthony NARDONE, Angie ROSE, Marta VALENCIANO and Lenka SOUČKOVÁ. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection. NA. Stockholm: ECDC European Centre for Disease Prevention and Control, 2021, 15 pp. NA.
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Basic information
Original name Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection
Authors BACCI, Sabrina (guarantor), Nathalie NICOLAY, Ester KISSLING, Anthony NARDONE, Angie ROSE, Marta VALENCIANO and Lenka SOUČKOVÁ (203 Czech Republic, belonging to the institution).
Edition NA. Stockholm, 15 pp. NA, 2021.
Publisher ECDC European Centre for Disease Prevention and Control
Other information
Original language English
Type of outcome Research report
Field of Study 30230 Other clinical medicine subjects
Country of publisher Sweden
Confidentiality degree is not subject to a state or trade secret
WWW COVID-19
RIV identification code RIV/00216224:14110/21:00123713
Organization unit Faculty of Medicine
Keywords (in Czech) COVID-19 vakcína; efektivita; Akutní respirační infekce
Keywords in English COVID-19 vaccine; effectiveness; Acute Respiratory Infection
Tags Excelence Science, International, RIV, rivok
Tags International impact
Changed by Changed by: Bc. Hana Vladíková, BBA, učo 244692. Changed: 13/1/2022 13:16.
Abstract
This document reports the first interim pooled estimates from the ECDC study of COVID-19 vaccine effectiveness (VE), conducted through the implementation of a multi-country approach using the Core protocol for ECDC studies of COVID-19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection laboratoryconfirmed with SARS-CoV-2, version 1.0 [1].Interim pooled estimates of COVID-19 VE were calculated for all COVID-19 vaccines deployed, including the COVID-19 mRNA vaccine Comirnaty (Pfizer/BioNTech), among hospitalised individuals aged 65 years and older with SARI due to laboratory-confirmed SARS-CoV-2, across EU/EEA participating countries. The study is currently ongoing and interim analyses will be conducted on a regular basis, with results updated as relevant. Pooled estimates are from patients recruited across several hospital study sites in the EU/EEA. These interim estimates mainly cover the pre-Delta period, adding further evidence to the existing literature on COVID-19 VE during this time. While VE estimates are important to inform vaccine recommendations, it is also important to ensure that robust methods were used to produce these estimates. Hence, this document presents a detailed description of both the methods used and the characteristics of the cases and controls enrolled in the study. For more details regarding the methods of the study, reference should be made to the core ECDC protocol [1].
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