KAISER, Karol, Ahram JANG, Petra KOMPANÍKOVÁ, Melody P. LUN, Jan PROCHAZKA, Ondrej MACHON, Neil DANI, Michaela PROCHAZKOVA, Benoit LAURENT, Daniel GYLLBORG, Renee VAN AMERONGEN, Ryann M. FAME, Suhasini GUPTA, Feizhen WU, Roger A. BARKER, Ivana BUKOVA, Radislav SEDLACEK, Zbynek KOZMIK, Ernest ARENAS, Maria K. LEHTINEN and Vítězslav BRYJA. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. Company of Biologists Ltd, 2021, vol. 148, No 10, p. "dev192054", 17 pp. ISSN 0950-1991. Available from: https://dx.doi.org/10.1242/dev.192054. |
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@article{1821641, author = {Kaiser, Karol and Jang, Ahram and Kompaníková, Petra and Lun, Melody P. and Prochazka, Jan and Machon, Ondrej and Dani, Neil and Prochazkova, Michaela and Laurent, Benoit and Gyllborg, Daniel and van Amerongen, Renee and Fame, Ryann M. and Gupta, Suhasini and Wu, Feizhen and Barker, Roger A. and Bukova, Ivana and Sedlacek, Radislav and Kozmik, Zbynek and Arenas, Ernest and Lehtinen, Maria K. and Bryja, Vítězslav}, article_number = {10}, doi = {http://dx.doi.org/10.1242/dev.192054}, keywords = {Choroid plexus; Epithelium; Meis1; Meis2; Morphogenesis; WNT5a}, language = {eng}, issn = {0950-1991}, journal = {Development}, title = {MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus}, url = {https://journals.biologists.com/dev/article/148/10/dev192054/268365/MEIS-WNT5A-axis-regulates-development-of-fourth}, volume = {148}, year = {2021} }
TY - JOUR ID - 1821641 AU - Kaiser, Karol - Jang, Ahram - Kompaníková, Petra - Lun, Melody P. - Prochazka, Jan - Machon, Ondrej - Dani, Neil - Prochazkova, Michaela - Laurent, Benoit - Gyllborg, Daniel - van Amerongen, Renee - Fame, Ryann M. - Gupta, Suhasini - Wu, Feizhen - Barker, Roger A. - Bukova, Ivana - Sedlacek, Radislav - Kozmik, Zbynek - Arenas, Ernest - Lehtinen, Maria K. - Bryja, Vítězslav PY - 2021 TI - MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus JF - Development VL - 148 IS - 10 SP - "dev192054" EP - "dev192054" PB - Company of Biologists Ltd SN - 09501991 KW - Choroid plexus KW - Epithelium KW - Meis1 KW - Meis2 KW - Morphogenesis KW - WNT5a UR - https://journals.biologists.com/dev/article/148/10/dev192054/268365/MEIS-WNT5A-axis-regulates-development-of-fourth N2 - The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development. Here, we show that epithelial WNT5A is crucial for determining fourth ventricle (4V) ChP morphogenesis and size in mouse. Systemic Wnt5a knockout, or forced Wnt5a overexpression beginning at embryonic day 10.5, profoundly reduced ChP size and development. However, Wnt5a expression was enriched in Foxj1-positive epithelial cells of 4V ChP plexus, and its conditional deletion in these cells affected the branched, villous morphology of the 4V ChP. We found that WNT5A was enriched in epithelial cells localized to the distal tips of 4V ChP villi, where WNT5A acted locally to activate non-canonical WNT signaling via ROR1 and ROR2 receptors. During 4V ChP development, MEIS1 bound to the proximal Wnt5a promoter, and gain- and loss-of-function approaches demonstrated that MEIS1 regulated Wnt5a expression. Collectively, our findings demonstrate a dual function of WNT5A in ChP development and identify MEIS transcription factors as upstream regulators of Wnt5a in the 4V ChP epithelium. ER -
KAISER, Karol, Ahram JANG, Petra KOMPANÍKOVÁ, Melody P. LUN, Jan PROCHAZKA, Ondrej MACHON, Neil DANI, Michaela PROCHAZKOVA, Benoit LAURENT, Daniel GYLLBORG, Renee VAN AMERONGEN, Ryann M. FAME, Suhasini GUPTA, Feizhen WU, Roger A. BARKER, Ivana BUKOVA, Radislav SEDLACEK, Zbynek KOZMIK, Ernest ARENAS, Maria K. LEHTINEN and Vítězslav BRYJA. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. \textit{Development}. Company of Biologists Ltd, 2021, vol.~148, No~10, p.~''dev192054'', 17 pp. ISSN~0950-1991. Available from: https://dx.doi.org/10.1242/dev.192054.
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