KOKOŠOVÁ, Viktória, Pavel FILIP, David KEC and Marek BALÁŽ. Bidirectional Association Between Sleep and Brain Atrophy in Aging. Frontiers in Aging Neuroscience. Lausanne: Frontiers, 2021, vol. 13, December 2021, p. 1-7. ISSN 1663-4365. Available from: https://dx.doi.org/10.3389/fnagi.2021.726662.
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Basic information
Original name Bidirectional Association Between Sleep and Brain Atrophy in Aging
Authors KOKOŠOVÁ, Viktória (703 Slovakia, guarantor, belonging to the institution), Pavel FILIP (703 Slovakia), David KEC (203 Czech Republic, belonging to the institution) and Marek BALÁŽ (703 Slovakia, belonging to the institution).
Edition Frontiers in Aging Neuroscience, Lausanne, Frontiers, 2021, 1663-4365.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.702
RIV identification code RIV/00216224:14110/21:00123751
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3389/fnagi.2021.726662
UT WoS 000732956300001
Keywords in English brain aging; sleep; neuroimaging; structural brain integrity; functional brain integrity
Tags 14110127, 14110221, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 17/5/2022 12:44.
Abstract
Human brain aging is characterized by the gradual deterioration of its function and structure, affected by the interplay of a multitude of causal factors. The sleep, a periodically repeating state of reversible unconsciousness characterized by distinct electrical brain activity, is crucial for maintaining brain homeostasis. Indeed, insufficient sleep was associated with accelerated brain atrophy and impaired brain functional connectivity. Concurrently, alteration of sleep-related transient electrical events in senescence was correlated with structural and functional deterioration of brain regions responsible for their generation, implying the interconnectedness of sleep and brain structure. This review discusses currently available data on the link between human brain aging and sleep derived from various neuroimaging and neurophysiological methods. We advocate the notion of a mutual relationship between the sleep structure and age-related alterations of functional and structural brain integrity, pointing out the position of high-quality sleep as a potent preventive factor of early brain aging and neurodegeneration. However, further studies are needed to reveal the causality of the relationship between sleep and brain aging.
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