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@article{1821821, author = {Kokošová, Viktória and Filip, Pavel and Kec, David and Baláž, Marek}, article_location = {Lausanne}, article_number = {December 2021}, doi = {http://dx.doi.org/10.3389/fnagi.2021.726662}, keywords = {brain aging; sleep; neuroimaging; structural brain integrity; functional brain integrity}, language = {eng}, issn = {1663-4365}, journal = {Frontiers in Aging Neuroscience}, title = {Bidirectional Association Between Sleep and Brain Atrophy in Aging}, url = {https://www.frontiersin.org/article/10.3389/fnagi.2021.726662}, volume = {13}, year = {2021} }
TY - JOUR ID - 1821821 AU - Kokošová, Viktória - Filip, Pavel - Kec, David - Baláž, Marek PY - 2021 TI - Bidirectional Association Between Sleep and Brain Atrophy in Aging JF - Frontiers in Aging Neuroscience VL - 13 IS - December 2021 SP - 1-7 EP - 1-7 PB - Frontiers SN - 16634365 KW - brain aging KW - sleep KW - neuroimaging KW - structural brain integrity KW - functional brain integrity UR - https://www.frontiersin.org/article/10.3389/fnagi.2021.726662 N2 - Human brain aging is characterized by the gradual deterioration of its function and structure, affected by the interplay of a multitude of causal factors. The sleep, a periodically repeating state of reversible unconsciousness characterized by distinct electrical brain activity, is crucial for maintaining brain homeostasis. Indeed, insufficient sleep was associated with accelerated brain atrophy and impaired brain functional connectivity. Concurrently, alteration of sleep-related transient electrical events in senescence was correlated with structural and functional deterioration of brain regions responsible for their generation, implying the interconnectedness of sleep and brain structure. This review discusses currently available data on the link between human brain aging and sleep derived from various neuroimaging and neurophysiological methods. We advocate the notion of a mutual relationship between the sleep structure and age-related alterations of functional and structural brain integrity, pointing out the position of high-quality sleep as a potent preventive factor of early brain aging and neurodegeneration. However, further studies are needed to reveal the causality of the relationship between sleep and brain aging. ER -
KOKOŠOVÁ, Viktória, Pavel FILIP, David KEC and Marek BALÁŽ. Bidirectional Association Between Sleep and Brain Atrophy in Aging. \textit{Frontiers in Aging Neuroscience}. Lausanne: Frontiers, 2021, vol.~13, December 2021, p.~1-7. ISSN~1663-4365. Available from: https://dx.doi.org/10.3389/fnagi.2021.726662.
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