Detailed Information on Publication Record
2022
Insights into deja vu: Associations between the frequency of experience and amplitudes of low-frequency oscillations in resting-state functional magnetic resonance imaging
ZATLOUKALOVÁ, Eva, Michal MIKL, Daniel Joel SHAW, Radek MAREČEK, Lenka SAKÁLOŠOVÁ et. al.Basic information
Original name
Insights into deja vu: Associations between the frequency of experience and amplitudes of low-frequency oscillations in resting-state functional magnetic resonance imaging
Authors
ZATLOUKALOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Lenka SAKÁLOŠOVÁ (703 Slovakia, belonging to the institution), Marie KUŘÁTKOVÁ (203 Czech Republic, belonging to the institution), Kristína MITTEROVÁ (703 Slovakia, belonging to the institution), Barbora SKLENÁROVÁ (703 Slovakia, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)
Edition
European Journal of Neuroscience, Hoboken, WILEY-BLACKWELL, 2022, 0953-816X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.400
RIV identification code
RIV/00216224:14110/22:00125188
Organization unit
Faculty of Medicine
UT WoS
000735105600001
Keywords in English
ALFF; default mode network; deja vu; fALFF; resting-state fMRI
Tags
International impact, Reviewed
Změněno: 17/10/2024 09:22, Mgr. Adéla Pešková
Abstract
V originále
The phenomenon of deja vu (DV) has intrigued scientists for decades, yet its neurophysiological underpinnings remain elusive. Brain regions have been identified in which morphometry differs between healthy individuals according to the frequency of their DV experiences. This study built upon these findings by assessing if and how neural activity in these and other brain regions also differ with respect to DV experience. Resting-state fMRI was performed on 68 healthy volunteers, 44 of whom reported DV experiences (DV group) and 24 who did not (NDV group). Using multivariate analyses, we then assessed the (fractional) amplitude of low-frequency fluctuations (fALFF/ALFF), a metric that is believed to index brain tissue excitability, for five discrete frequency bands within sets of brain regions implicated in DV and those comprising the default mode network (DMN). Analyses revealed significantly lower values of fALFF/ALFF for specific frequency bands in the DV relative to the NDV group, particularly within mesiotemporal structures, bilateral putamina, right caudatum, bilateral superior frontal cortices, left lateral parietal cortex, dorsal and ventral medial prefrontal cortex, and the posterior cingulate cortex. The pattern of differences in fALFF/ALFF measures between the brains of individuals who have experienced DV and those who have not provides new neurophysiological insights into this phenomenon, including the potential role of the DMN. We suggest that the erroneous feeling of familiarity arises from a temporary disruption of cortico-subcortical circuitry together with the upregulation of cortical excitability.
Links
| EF16_013/0001775, research and development project |
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| 90129, large research infrastructures |
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