Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry
FILIP, Pavel, Michal DUFEK, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ et. al.
Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry
Authors
FILIP, Pavel (703 Slovakia), Michal DUFEK (203 Czech Republic, belonging to the institution), Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ (203 Czech Republic, belonging to the institution), Daniel SCHWARZ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Lubomír VOJTÍŠEK (203 Czech Republic, guarantor, belonging to the institution)
Edition
Frontiers in Neuroscience, Lausanne, Frontiers Media S.A. 2021, 1662-453X
Background: The research of primary progressive multiple sclerosis (PPMS) has not been able to capitalize on recent progresses in advanced magnetic resonance imaging (MRI) protocols.
Objective: The presented cross-sectional study evaluated the utility of four different MRI relaxation metrics and diffusion-weighted imaging in PPMS.
Methods: Conventional free precession T1 and T2, and rotating frame adiabatic T1 rho and T2 rho in combination with diffusion-weighted parameters were acquired in 13 PPMS patients and 13 age- and sex-matched controls.
Results: T1 rho, a marker of crucial relevance for PPMS due to its sensitivity to neuronal loss, revealed large-scale changes in mesiotemporal structures, the sensorimotor cortex, and the cingulate, in combination with diffuse alterations in the white matter and cerebellum. T2 rho, particularly sensitive to local tissue background gradients and thus an indicator of iron accumulation, concurred with similar topography of damage, but of lower extent. Moreover, these adiabatic protocols outperformed both conventional T1 and T2 maps and diffusion tensor/kurtosis approaches, methods previously used in the MRI research of PPMS.
Conclusion: This study introduces adiabatic T1 rho and T2 rho as elegant markers confirming large-scale cortical gray matter, cerebellar, and white matter alterations in PPMS invisible to other in vivo biomarkers.
Links
LQ1601, research and development project
Name: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
FILIP, Pavel, Michal DUFEK, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ, Daniel SCHWARZ, Ivan REKTOR and Lubomír VOJTÍŠEK. Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry. Frontiers in Neuroscience. Lausanne: Frontiers Media S.A., 2021, vol. 15, September 2021, p. 1-10. ISSN 1662-453X. Available from: https://dx.doi.org/10.3389/fnins.2021.711067.
@article{1823197, author = {Filip, Pavel and Dufek, Michal and Mangia, Silvia and Michaeli, Shalom and Bareš, Martin and Schwarz, Daniel and Rektor, Ivan and Vojtíšek, Lubomír}, article_location = {Lausanne}, article_number = {September 2021}, doi = {http://dx.doi.org/10.3389/fnins.2021.711067}, keywords = {primary progressive multiple sclerosis; T1 mapping; T2 mapping; diffusion weighted imaging; DWI; adiabatic T1 rho mapping; adiabatic T2 rho mapping}, language = {eng}, issn = {1662-453X}, journal = {Frontiers in Neuroscience}, title = {Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry}, url = {https://www.frontiersin.org/articles/10.3389/fnins.2021.711067/full}, volume = {15}, year = {2021} }
TY - JOUR ID - 1823197 AU - Filip, Pavel - Dufek, Michal - Mangia, Silvia - Michaeli, Shalom - Bareš, Martin - Schwarz, Daniel - Rektor, Ivan - Vojtíšek, Lubomír PY - 2021 TI - Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry JF - Frontiers in Neuroscience VL - 15 IS - September 2021 SP - 1-10 EP - 1-10 PB - Frontiers Media S.A. SN - 1662453X KW - primary progressive multiple sclerosis KW - T1 mapping KW - T2 mapping KW - diffusion weighted imaging KW - DWI KW - adiabatic T1 rho mapping KW - adiabatic T2 rho mapping UR - https://www.frontiersin.org/articles/10.3389/fnins.2021.711067/full N2 - Background: The research of primary progressive multiple sclerosis (PPMS) has not been able to capitalize on recent progresses in advanced magnetic resonance imaging (MRI) protocols.
Objective: The presented cross-sectional study evaluated the utility of four different MRI relaxation metrics and diffusion-weighted imaging in PPMS.
Methods: Conventional free precession T1 and T2, and rotating frame adiabatic T1 rho and T2 rho in combination with diffusion-weighted parameters were acquired in 13 PPMS patients and 13 age- and sex-matched controls.
Results: T1 rho, a marker of crucial relevance for PPMS due to its sensitivity to neuronal loss, revealed large-scale changes in mesiotemporal structures, the sensorimotor cortex, and the cingulate, in combination with diffuse alterations in the white matter and cerebellum. T2 rho, particularly sensitive to local tissue background gradients and thus an indicator of iron accumulation, concurred with similar topography of damage, but of lower extent. Moreover, these adiabatic protocols outperformed both conventional T1 and T2 maps and diffusion tensor/kurtosis approaches, methods previously used in the MRI research of PPMS.
Conclusion: This study introduces adiabatic T1 rho and T2 rho as elegant markers confirming large-scale cortical gray matter, cerebellar, and white matter alterations in PPMS invisible to other in vivo biomarkers.
ER -
FILIP, Pavel, Michal DUFEK, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ, Daniel SCHWARZ, Ivan REKTOR and Lubomír VOJTÍŠEK. Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry. \textit{Frontiers in Neuroscience}. Lausanne: Frontiers Media S.A., 2021, vol.~15, September 2021, p.~1-10. ISSN~1662-453X. Available from: https://dx.doi.org/10.3389/fnins.2021.711067.