J 2021

Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease

BOČKOVÁ, Martina, Eva VÝTVAROVÁ, Martin LAMOŠ, P. KLIMES, P. JURAK et. al.

Basic information

Original name

Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease

Authors

BOČKOVÁ, Martina (203 Czech Republic, belonging to the institution), Eva VÝTVAROVÁ (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), P. KLIMES, P. JURAK, J. HALAMEK, Sabina GOLDEMUNDOVÁ (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Human Brain mapping, Hoboken, WILEY-BLACKWELL, 2021, 1065-9471

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.399

RIV identification code

RIV/00216224:14740/21:00119591

Organization unit

Central European Institute of Technology

DOI

UT WoS

000689718000001

Keywords in English

deep brain stimulation; high-density EEG; network analysis; subthalamic nucleus

Tags

Tags

International impact, Reviewed
Změněno: 9/10/2024 12:29, Ing. Jana Kuchtová

Abstract

V originále

The degree of response to subthalamic nucleus deep brain stimulation (STN-DBS) is individual and hardly predictable. We hypothesized that DBS-related changes in cortical network organization are related to the clinical effect. Network analysis based on graph theory was used to evaluate the high-density electroencephalography (HDEEG) recorded during a visual three-stimuli paradigm in 32 Parkinson's disease (PD) patients treated by STN-DBS in stimulation "off" and "on" states. Preprocessed scalp data were reconstructed into the source space and correlated to the behavioral parameters. In the majority of patients (n = 26), STN-DBS did not lead to changes in global network organization in large-scale brain networks. In a subgroup of suboptimal responders (n = 6), identified according to reaction times (RT) and clinical parameters (lower Unified Parkinson's Disease Rating Scale [UPDRS] score improvement after DBS and worse performance in memory tests), decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas were detected. The important role of the supplementary motor area for the optimal DBS response was demonstrated by the increased node strength and eigenvector centrality in good responders. This response was missing in the suboptimal responders. Cortical topologic architecture is modified by the response to STN-DBS leading to a dysfunction of the large-scale networks in suboptimal responders.

Links

GA21-25953S, research and development project
Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)
Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective
NU21-04-00445, research and development project
Name: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Acronym: DBScomorbidities)
Investor: Ministry of Health of the CR, STN-DBS outcomes in Parkinson´s disease: the influence of vascular, cardiovascular, metabolic, and inflammatory co-morbidities., Subprogram 1 - standard
90129, large research infrastructures
Name: Czech-BioImaging II